Diagnostic Unit for Amyloidosis, Department of Laboratory Medicine, Kumamoto University Hospital, 1-1-1 Honjo, Kumamoto 860-8556, Japan.
Clin Chim Acta. 2013 Oct 21;425:196-201. doi: 10.1016/j.cca.2013.07.028. Epub 2013 Aug 9.
Of the major diagnostic specimen types, saliva is one of the most easily collected. Many studies have focused on the evaluation of salivary proteins secreted by healthy people and patients with various diseases during responses to acute mental stress. In particular, such studies have focused on cortisol, α-amylase, chromogranin A (CgA), and immunoglobulin A (IgA) as salivary stress markers. Each of these salivary stress markers has its own strengths and weaknesses as well as data gaps related to many factors including collection technique. In this review, we summarize the critical knowledge of the positive and negative attributes and data gaps pertaining to each salivary stress marker.
在主要的诊断标本类型中，唾液是最容易采集的一种。许多研究都集中在评估健康人群和各种疾病患者在急性精神应激反应中分泌的唾液蛋白。特别是，这些研究集中在皮质醇、α-淀粉酶、嗜铬粒蛋白 A（CgA）和免疫球蛋白 A（IgA）作为唾液应激标志物上。这些唾液应激标志物中的每一种都有其自身的优缺点，以及与包括采集技术在内的许多因素相关的数据空白。在这篇综述中，我们总结了每个唾液应激标志物的积极和消极属性以及数据空白的关键知识。
