Teva Neuroscience, Inc., Kansas City, MO 64131, USA.
J Parkinsons Dis. 2011;1(3):253-8. doi: 10.3233/JPD-2011-11035.
Administering items or subscales separately from the measure for which they were designed to be a part may have unintended consequences for research and practice in Parkinson's disease (PD). The current study tested the equivalence of the bradykinesia subscale when administered alone versus as a component of the full 14-item Unified Parkinson's Disease Rating Scale (UPDRS) motor examination, as well as examined the reliability and validity of the bradykinesia subscale. The study sample consisted of 112 patients with PD. Patients were randomly assigned to either the bradykinesia subscale alone group (n = 56), who were administered the bradykinesia subscale separately from the rest of the UPDRS motor examination, or the full scale group (n = 56), who were administered the UPDRS motor examination in its standard format. The two one-sided t-test (TOST) procedure was used to test for mean equivalency between the two administration groups. Additionally, reliability and validity analyses were performed. The bradykinesia subscale mean scores from the full scale group and the subscale alone group were not statistically equivalent. However, in both groups, the bradykinesia subscale had exceptional reliability and was strongly and similarly related to age, activities of daily living, disability, and other assessments of motor symptom severity. The bradykinesia subscale is a valid and reliable assessment when administered separately from the rest of the UPDRS motor examination; however, caution should be taken when comparing mean scores across studies or occasions when different administrations are used.
将项目或子量表与设计为其组成部分的测量分开管理，可能会对帕金森病（PD）的研究和实践产生意想不到的后果。本研究测试了在单独管理与作为完整的 14 项统一帕金森病评定量表（UPDRS）运动检查的一部分时，运动迟缓子量表的等效性，以及运动迟缓子量表的可靠性和有效性。研究样本包括 112 名 PD 患者。患者被随机分配到运动迟缓子量表单独组（n = 56）或全量表组（n = 56）。运动迟缓子量表单独组单独管理运动迟缓子量表，而全量表组则以标准格式管理 UPDRS 运动检查。使用双侧单边 t 检验（TOST）程序测试两组之间的平均等效性。此外，还进行了可靠性和有效性分析。全量表组和子量表单独组的运动迟缓子量表平均得分在统计学上没有差异。然而，在这两组中，运动迟缓子量表具有极好的可靠性，并且与年龄、日常生活活动、残疾和其他运动症状严重程度评估密切相关。当从 UPDRS 运动检查的其余部分单独管理时，运动迟缓子量表是一种有效且可靠的评估方法；但是，当在不同的研究或场合比较平均得分时，或当使用不同的管理方式时，应谨慎行事。
