Department of Neurology and Neurosurgery, Montreal Neurological Institute & Hospital, McGill University, Montreal, Quebec, Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.
J Neurosci Methods. 2013 Oct 15;219(2):220-3. doi: 10.1016/j.jneumeth.2013.08.009. Epub 2013 Aug 16.
Bradykinesia is usually assessed using clinical rating scales. In some circumstances, a laboratory assessment of bradykinesia using tools of higher resolution is required. One task often used for the evaluation of bradykinesia is a rapid alternating movement (RAM) of the hand. However, the relationship between clinical scores of bradykinesia and the properties of a RAM task assessed quantitatively has yet to be determined.
Identify which of the commonly used properties of a RAM task are related to a clinical score of bradykinesia and assess the strength of this relationship.
Nineteen patients with idiopathic Parkinson's disease were tested ON and OFF medication. They performed three trials of the RAM task and were assessed clinically using the Unified Parkinson's disease rating scale in each condition and with each hand.
A statistically significant correlation was observed between the clinical score of bradykinesia and two of the properties of the RAM task; namely mean and maximal velocity.
These results indicate that a RAM task does provide a measure of bradykinesia but it is only moderately correlated to a clinical rating of this motor symptom.
We propose that the results from the RAM task represent a measure of "core bradykinesia" while a clinical evaluation represents a composite score of bradykinesia, movement amplitude and motor coordination.
运动徐缓通常使用临床评分量表进行评估。在某些情况下，可能需要使用分辨率更高的实验室工具来评估运动徐缓。手部快速交替运动（RAM）是常用于评估运动徐缓的一项任务。然而，运动徐缓的临床评分与定量评估的 RAM 任务的特性之间的关系尚未确定。
确定 RAM 任务的常用特性中哪些与运动徐缓的临床评分相关，并评估这种关系的强度。
19 名特发性帕金森病患者在用药和停药状态下接受测试。他们在每种情况下和每只手上完成三次 RAM 任务的试验，并使用统一帕金森病评定量表进行临床评估。
运动徐缓的临床评分与 RAM 任务的两个特性（即平均速度和最大速度）之间存在统计学显著相关性。
这些结果表明，RAM 任务确实提供了运动徐缓的测量方法，但与这种运动症状的临床评分仅有中度相关性。
我们提出，RAM 任务的结果代表“核心运动徐缓”的测量方法，而临床评估则代表运动徐缓、运动幅度和运动协调性的综合评分。
