Houston VA Health Services Research and Development Center of Excellence, Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA.
J Parkinsons Dis. 2012;2(2):135-51. doi: 10.3233/JPD-2012-12080.
Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is generally defined by its progressive motor features; but increased attention is being paid to its non-motor neuropsychiatric symptoms, which profoundly impact quality of life for patients and caregivers. Anxiety and depression are particularly problematic and are the strongest predictors of quality of life in PD. Recent research has focused on non-pharmacological approaches to treating depression and anxiety in patients with PD. Cognitive-behavioral therapy (CBT) is a potentially efficacious non-pharmacological treatment for mood and anxiety symptoms associated with PD. Accordingly, this review examines empirical studies of CBT-based treatments for depression and anxiety symptoms in PD. Medical Subject Headings were used in searches of PsychInfo and PubMed of English-language articles published in peer-reviewed journals, resulting in the identification of 10 articles. Four additional articles were identified from the references of these articles and upon the suggestions of experts, for 15 articles in all. Results of individual studies varied significantly; however, the randomized controlled trials showed encouraging results and support the need for further investigation of the utility of CBT for depressed and anxious patients with PD. CBT is potentially a useful treatment for patients with PD and comorbid depression and/or anxiety, but more systematic research will be necessary to measure its effects.
帕金森病（PD）是第二常见的神经退行性疾病。它通常被定义为其进行性运动特征；但人们越来越关注其非运动性神经精神症状，这些症状严重影响了患者和护理人员的生活质量。焦虑和抑郁尤为突出，是 PD 患者生活质量的最强预测因素。最近的研究集中在非药物治疗帕金森病患者的抑郁和焦虑上。认知行为疗法（CBT）是一种针对与 PD 相关的情绪和焦虑症状的潜在有效非药物治疗方法。因此，本综述检查了针对 PD 患者抑郁和焦虑症状的基于 CBT 的治疗的实证研究。使用医学主题词在 PsychInfo 和 PubMed 中搜索发表在同行评议期刊上的英文文章，共确定了 10 篇文章。从这些文章的参考文献中还确定了另外 4 篇文章，并根据专家的建议，共确定了 15 篇文章。个别研究的结果差异很大；然而，随机对照试验结果令人鼓舞，支持进一步研究 CBT 对患有抑郁和焦虑的 PD 患者的效用。CBT 可能是 PD 合并抑郁和/或焦虑患者的一种有用治疗方法，但需要进行更系统的研究来衡量其效果。
