Ren Hao, Zhou Yilun, Lv Yuanyuan, Liu Xiaojie, He Lingxiao, Yu Laikang
Beijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University, Beijing 100084, China.
Department of Strength and Conditioning Assessment and Monitoring, Beijing Sport University, Beijing 100084, China.
Brain Sci. 2025 Jul 25;15(8):792. doi: 10.3390/brainsci15080792.
: The objective of this study was to assess the effect of aerobic exercise on depressive symptoms and to determine the optimal exercise prescription for Parkinson's disease (PD) patients. : A comprehensive search was conducted across PubMed, Web of Science, Cochrane, Scopus, and Embase databases. A meta-analysis was conducted to determine the standardized mean difference (SMD) and 95% confidence interval. : Aerobic exercise significantly alleviated depressive symptoms in PD patients (SMD, -0.68, = 0.002). Subgroup analyses revealed that moderate intensity aerobic exercise (SMD, -0.72, = 0.0006), interventions conducted for ≥12 weeks (SMD, -0.85, = 0.04), ≥3 times per week (SMD, -0.68, = 0.002), ≥60 min per session (SMD, -0.57, < 0.0001), and ≥180 min per week (SMD, -0.87, = 0.0002) were more effective in improving depressive symptoms in PD patients, especially in PD patients with a disease duration of ≤6 years (SMD, -1.00, = 0.04). : Integrating the available data, it is clear that aerobic exercise is a proven method for alleviating depressive symptoms in PD patients. This meta-analysis provides empirical support for clinicians to recommend that PD patients engage in aerobic exercise regimens of no less than 12 weeks' duration, performed at a minimum frequency of three sessions per week, with each session lasting in excess of 60 min and a cumulative weekly duration of at least 180 min, to effectively attenuate depressive symptomatology. Earlier implementation of aerobic exercise interventions is recommended, as PD patients in the early stages of the disease (up to 6 years post-diagnosis) may derive the greatest benefit in terms of depression symptom improvement from such programs.
本研究的目的是评估有氧运动对抑郁症状的影响，并确定帕金森病（PD）患者的最佳运动处方。对PubMed、科学网、考科蓝、Scopus和Embase数据库进行了全面检索。进行荟萃分析以确定标准化平均差（SMD）和95%置信区间。有氧运动显著减轻了PD患者的抑郁症状（SMD，-0.68，P = 0.002）。亚组分析显示，中等强度有氧运动（SMD，-0.72，P = 0.0006）、持续≥12周的干预（SMD，-0.85，P = 0.04）、每周≥3次（SMD，-0.68，P = 0.002）、每次≥60分钟（SMD，-0.57，P < 0.0001）以及每周≥180分钟（SMD，-0.87，P = 0.0002）在改善PD患者抑郁症状方面更有效，尤其是疾病持续时间≤6年的PD患者（SMD，-1.00，P = 0.04）。综合现有数据，很明显有氧运动是减轻PD患者抑郁症状的一种经证实的方法。这项荟萃分析为临床医生提供了实证支持，建议PD患者进行持续不少于12周的有氧运动方案，每周至少进行三次，每次持续超过60分钟，每周累计持续时间至少180分钟，以有效减轻抑郁症状。建议尽早实施有氧运动干预，因为处于疾病早期（诊断后6年内）的PD患者可能从此类方案中在改善抑郁症状方面获得最大益处。
