Cai B C, Hattori M, Namba T
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1990 May;38(5):1295-8. doi: 10.1248/cpb.38.1295.
In the course of our study on the drug-processing of the seeds of Strychnos nux-vomica L. (Loganiaceae), the alkaloid composition of the heat-treated seeds of S. nux-vomica was compared to that of the untreated seeds. On heat treatment, the contents of the major alkaloids such as strychnine and brucine declined significantly with increases in the amounts of isostrychnine, isobrucine, strychnine N-oxide and brucine N-oxide. The cleavage of an ether linkage and the occurrence of N-oxidation were demonstrated by heat treatment of authentic strychnine and brucine.
在我们对马钱子（马钱科）种子炮制的研究过程中，将热处理后的马钱子种子的生物碱成分与未处理种子的进行了比较。热处理时，士的宁和马钱子碱等主要生物碱的含量显著下降，而异士的宁、异马钱子碱、士的宁N -氧化物和马钱子碱N -氧化物的含量增加。通过对纯正的士的宁和马钱子碱进行热处理，证实了醚键的断裂和N -氧化反应的发生。
