Department of Emergency Medicine, Division of Medical Toxicology Virginia Commonwealth University Health System, USA.
Division of Medical Toxicology Virginia Commonwealth University Health System, Richmond, VA, USA.
Toxicon. 2021 Sep;200:1-2. doi: 10.1016/j.toxicon.2021.06.014. Epub 2021 Jun 25.
The St. Ignatius bean of the Strychnos ignatii tree and Nux Vomica homeopathic products presumably could contain the toxic alkaloids strychnine and brucine. This study aimed to determine the amount of these toxic alkaloids in some commercially available Nux Vomica products and the St. Ignatius bean and to determine if overdose of these products could result in clinically significant toxicity.
Using ultra-performance liquid chromatography-tandem mass spectrometry, various formulations of Nux Vomica products and St. Ignatius beans were analyzed for strychnine, and brucine with detection limits set at 0.1 ng/g.
None of the analyzed Nux Vomica products contained any detectable strychnine or brucine, while the expected strychnine dose from a St. Ignatius bean would be < 0.001 mg.
Overall, our study reveals that the amount of strychnine in homeopathic Nux Vomica products or St. Ignatius beans are not likely to result in clinically significant strychnine toxicity.
原产于马钱科植物马钱子的士的宁豆和顺势疗法产品 presumably 可能含有有毒生物碱士的宁和番木鳖碱。本研究旨在测定一些市售的顺势疗法产品和士的宁豆中这些有毒生物碱的含量，并确定过量使用这些产品是否会导致临床上显著的毒性。
采用超高效液相色谱-串联质谱法，对各种 Nux Vomica 产品和士的宁豆进行士的宁和番木鳖碱分析，检测限设定为 0.1ng/g。
分析的 Nux Vomica 产品均未检出士的宁或番木鳖碱，而一颗士的宁豆中士的宁的预期剂量 < 0.001mg。
总的来说，我们的研究表明，顺势疗法 Nux Vomica 产品或士的宁豆中的士的宁含量不太可能导致临床上显著的士的宁毒性。
