Noro T, Ehara M, Ueno A
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Chem Pharm Bull (Tokyo). 1990 May;38(5):1403-4. doi: 10.1248/cpb.38.1403.
Inhibitory activities of Dipyridamole (DPM, 2,6-bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)py rim idine) against xanthine oxidase (XO), carbonic anhydorase (CA) and monoamine oxidase (MAO) were studied, in vitro. DPM did not inhibit XO and CA, but it strongly inhibited MAO. The type of inhibition by DPM against MAO with respect to benzylamine as a substrate was uncompetitive.
研究了双嘧达莫（DPM，2,6-双（二乙醇氨基）-4,8-二哌啶基嘧啶并[5,4-d]嘧啶）在体外对黄嘌呤氧化酶（XO）、碳酸酐酶（CA）和单胺氧化酶（MAO）的抑制活性。双嘧达莫不抑制XO和CA，但强烈抑制MAO。以苄胺为底物时，双嘧达莫对MAO的抑制类型为非竞争性。
