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11α-乙氧基-β-乳香酸和尼万酮,分别是乳香中的一种新的乳香酸衍生物和一种新的三萜。

11α-Ethoxy-β-boswellic acid and nizwanone, a new boswellic acid derivative and a new triterpene, respectively, from Boswellia sacra.

机构信息

Department of Biological Sciences and Chemistry, University of Nizwa, P.O. Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman.

出版信息

Chem Biodivers. 2013 Aug;10(8):1501-6. doi: 10.1002/cbdv.201200231.

Abstract

A new boswellic acid derivative, 11α-ethoxy-β-boswellic acid (EBA; 1) and a new ursane-type triterpene, named nizwanone (2), were isolated from Omani frankincense Boswellia sacra Flueck. together with two known compounds papyriogenin B and rigidenol. The structures of 1 and 2 were elucidated by detailed spectroscopic analysis using (1) H- and (13) C-NMR, (1) H,(1) H-COSY, HMQC, HMBC, and HR-EI-MS techniques. The relative configurations of 1 and 2 were assigned by comparative analysis of the NMR spectral data with those of known analogs together with NOESY experiments. Structures of known compounds were identified by comparison with the reported data.

摘要

从阿曼乳香树 Boswellia sacra Flueck. 中分离得到了一种新的 Boswellic 酸衍生物,11α-乙氧基-β-Boswellic 酸 (EBA; 1) 和一种新的 Ursane 型三萜,命名为 Nizwanone (2),以及两种已知化合物 papyriogenin B 和 rigidenol。通过使用 (1) H- 和 (13) C-NMR、(1) H,(1) H-COSY、HMQC、HMBC 和 HR-EI-MS 技术的详细光谱分析,阐明了 1 和 2 的结构。通过与已知类似物的 NMR 光谱数据进行比较分析以及 NOESY 实验,确定了 1 和 2 的相对构型。通过与报道的数据进行比较,确定了已知化合物的结构。

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