碳青霉烯类耐药鲍曼不动杆菌全球克隆 2 在亚洲的传播和 AbaR 型耐药岛。
Spread of carbapenem-resistant Acinetobacter baumannii global clone 2 in Asia and AbaR-type resistance islands.
机构信息
Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea.
出版信息
Antimicrob Agents Chemother. 2013 Nov;57(11):5239-46. doi: 10.1128/AAC.00633-13. Epub 2013 Aug 12.
Abstract
In this surveillance study, we identified the genotypes, carbapenem resistance determinants, and structural variations of AbaR-type resistance islands among carbapenem-resistant Acinetobacter baumannii (CRAB) isolates from nine Asian locales. Clonal complex 92 (CC92), corresponding to global clone 2 (GC2), was the most prevalent in most Asian locales (83/108 isolates; 76.9%). CC108, or GC1, was a predominant clone in India. OXA-23 oxacillinase was detected in CRAB isolates from most Asian locales except Taiwan. blaOXA-24 was found in CRAB isolates from Taiwan. AbaR4-type resistance islands, which were divided into six subtypes, were identified in most CRAB isolates investigated. Five isolates from India, Malaysia, Singapore, and Hong Kong contained AbaR3-type resistance islands. Of these, three isolates harbored both AbaR3- and AbaR4-type resistance islands simultaneously. In this study, GC2 was revealed as a prevalent clone in most Asian locales, with the AbaR4-type resistance island predominant, with diverse variants. The significance of this study lies in identifying the spread of global clones of carbapenem-resistant A. baumannii in Asia.
摘要
在这项监测研究中，我们鉴定了来自亚洲九个地区的耐碳青霉烯鲍曼不动杆菌（CRAB）分离株中 AbaR 型耐药岛的基因型、碳青霉烯耐药决定因子和结构变异。克隆复合体 92（CC92），对应于全球克隆 2（GC2），在大多数亚洲地区最为流行（83/108 株；76.9%）。CC108 或 GC1 是印度的主要克隆。除台湾外，大多数亚洲地区的 CRAB 分离株均检测到 OXA-23 青霉素酶。台湾的 CRAB 分离株中发现了 blaOXA-24。在大多数调查的 CRAB 分离株中发现了 AbaR4 型耐药岛，可分为六个亚型。来自印度、马来西亚、新加坡和中国香港的五株分离株含有 AbaR3 型耐药岛。其中三株同时携带 AbaR3 和 AbaR4 型耐药岛。在这项研究中，GC2 被揭示为大多数亚洲地区流行的克隆，以 AbaR4 型耐药岛为主，具有多种变体。这项研究的意义在于确定耐碳青霉烯鲍曼不动杆菌的全球克隆在亚洲的传播。
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