Iskra R Ia, Vlizlo V V
Ukr Biokhim Zh (1999). 2013 May-Jun;85(3):96-102. doi: 10.15407/ubj85.03.096.
The influence of CrCI3 in the amount of 400 mg Cr/kg of feed on antioxidant defense in populations of erythrocytes, erythroid bone marrow cells and tissues of pigs was studied. The increasing of the antioxidant defense of swine organism, as evidenced by the increase in superoxide dismutase and glutathione peroxidase activity in the fractions of "young" erythrocytes, was shown. Superoxide dismutase activity decreases, while glutathione and catalase activity increases in the erythroid cells of the bone marrow after of CrCl3 action. Oxidative processes are intensified in the liver of pigs of the experimental group, in contrast to other tissues, leading to the increase of content of TBARS-products, growth of superoxide dismutase activity and reduction of glutathione peroxidase activity. At the same time, the action of CrCl3 in other tissues activates antioxidant system, including the kidneys, lungs and myocardium, increases superoxide dismutase activity, and catalase activity in the spleen and kidneys. A decrease of content of TBARS-products and reduction of superoxide dismutase activity, as well as the increase of katalase activity and reduction of glutathione content were discovered in the skeletal muscles of pigs of the experimental group. As a result of research it is suggested to add CrCl3 to the diet of pigs to enhance antioxidant defense during their intensive growth.
研究了饲料中添加400mg铬/千克氯化铬（CrCI3）对猪红细胞群体、红系骨髓细胞和组织抗氧化防御的影响。结果表明，“年轻”红细胞组分中超氧化物歧化酶和谷胱甘肽过氧化物酶活性增加，证明猪机体的抗氧化防御能力增强。氯化铬作用后，骨髓红系细胞中超氧化物歧化酶活性降低，而谷胱甘肽和过氧化氢酶活性增加。与其他组织相比，实验组猪肝脏中的氧化过程加剧，导致丙二醛产物含量增加、超氧化物歧化酶活性增强和谷胱甘肽过氧化物酶活性降低。同时，氯化铬在其他组织（包括肾脏、肺和心肌）中的作用激活了抗氧化系统，增加了超氧化物歧化酶活性，以及脾脏和肾脏中的过氧化氢酶活性。在实验组猪的骨骼肌中发现丙二醛产物含量降低、超氧化物歧化酶活性降低，以及过氧化氢酶活性增加和谷胱甘肽含量降低。研究结果表明，在猪的集约化生长期间，建议在其日粮中添加氯化铬以增强抗氧化防御能力。
