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多导生理记录仪与多导睡眠图:有症状打鼾者中阻塞性睡眠呼吸暂停的漏诊——给临床医生的一个提醒

Polygraphy vs. polysomnography: missing osas in symptomatic snorers--a reminder for clinicians.

作者信息

Nerfeldt P, Aoki F, Friberg D

机构信息

Department of Oto-Rhino-Laryngology, Karolinska University Hospital, Stockholm, Sweden,

出版信息

Sleep Breath. 2014 May;18(2):297-303. doi: 10.1007/s11325-013-0884-6. Epub 2013 Aug 14.

Abstract

PURPOSES

The purposes of this study are to investigate the usefulness of polygraphy (PG) in diagnosing obstructive sleep apnea (OSA) in sleepy/tired snorers compared to polysomnography (PSG) and, further, to search for suspected respiratory arousals in the PG.

METHODS

One hundred eighty-seven adults suffering from sleepiness/tiredness and snoring had undergone ambulant PG and were considered to be normal, using American Academy of Sleep Medicine's 2007 hypopnea criteria A. After approximately 7 months, in-lab PSG was performed using hypopnea criteria B, where arousals are also recognized. Validated questionnaires (Hospital Anxiety and Depression Scale, self-rated general health) were answered. In a subgroup, the sensitivity and specificity were calculated for flow limitation index (FLI) and flattening index (FlatI) in PG compared with the respiratory distress index (RDI) in PSG.

RESULTS

Despite the normal PG, at PSG, the median RDI was 11.0 (range, 0-89.1). One hundred sixty-eight out of one hundred seventy-eight (90%) were found to have at least mild OSA and 119/187 (64%) with moderate-severe OSA according to the RDI values. The sensitivity and specificity were low (<70%) for FLI and FlatI. Forty-nine percent of the patients rated anxiety at borderline or pathological levels, 35% rated corresponding depression levels, and 45% rated poor or fair general health.

CONCLUSIONS

PG was insufficient to rule out OSA when the respiratory events were mainly associated with arousals. Almost half of these patients experience low general health and psychiatric problems. We recommend a full-night PSG when PG is "normal", and patients have symptoms of snoring and sleepiness/tiredness.

摘要

目的

本研究的目的是调查与多导睡眠图(PSG)相比,多导记录法(PG)在诊断困倦/疲惫打鼾者阻塞性睡眠呼吸暂停(OSA)中的实用性,并进一步在PG中寻找疑似呼吸唤醒。

方法

187名患有嗜睡/疲惫和打鼾的成年人接受了便携式PG检查,并根据美国睡眠医学学会2007年的低通气标准A被认为是正常的。大约7个月后,使用低通气标准B进行实验室PSG检查,其中唤醒也被识别。回答了经过验证的问卷(医院焦虑和抑郁量表、自评总体健康状况)。在一个亚组中,计算了PG中的气流受限指数(FLI)和平坦指数(FlatI)与PSG中的呼吸窘迫指数(RDI)相比的敏感性和特异性。

结果

尽管PG正常,但在PSG检查中,RDI的中位数为11.0(范围为0 - 89.1)。根据RDI值,178名患者中有168名(90%)被发现至少患有轻度OSA,119/187(64%)患有中度至重度OSA。FLI和FlatI的敏感性和特异性较低(<70%)。49%的患者焦虑评分处于临界或病理水平,35%的患者抑郁评分处于相应水平,45%的患者总体健康状况评为差或一般。

结论

当呼吸事件主要与唤醒相关时,PG不足以排除OSA。这些患者中几乎一半存在总体健康状况不佳和精神问题。我们建议当PG“正常”但患者有打鼾和嗜睡/疲惫症状时进行整夜PSG检查。

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