母亲6-硫鸟嘌呤核苷酸水平在预测新生儿全血细胞减少症中的效用。
Utility of maternal 6-thioguanine nucleotide levels in predicting neonatal pancytopenia.
作者信息
Maruyama Hidehiko, Tada Katsuhiko, Fujiwara Takuzo, Ota Kosuke, Kageyama Misao
机构信息
Department of Neonatology, National Hospital Organization, Okayama Medical Center, Okayama, Japan.
出版信息
AJP Rep. 2013 May;3(1):25-8. doi: 10.1055/s-0032-1329683. Epub 2012 Dec 3.
Abstract
An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 10(8) red blood cells, respectively. Maternal 6TGN levels could be useful in predicting neonatal pancytopenia.
摘要
一名全血细胞减少的婴儿，其母亲曾使用常见免疫抑制剂硫唑嘌呤（AZA）。母亲和新生儿血液中6-硫鸟嘌呤核苷酸（6TGN，AZA的代谢产物）水平分别为1890和1480 pmol/8×10⁸红细胞。母亲的6TGN水平可能有助于预测新生儿全血细胞减少。
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