寻常型天疱疮患者中硫唑嘌呤向6-硫鸟嘌呤核苷酸的代谢
Metabolism of azathioprine to 6-thioguanine nucleotides in patients with pemphigus vulgaris.
作者信息
Lennard L, Harrington C I, Wood M, Maddocks J L
出版信息
Br J Clin Pharmacol. 1987 Feb;23(2):229-33. doi: 10.1111/j.1365-2125.1987.tb03034.x.
Abstract
Azathioprine metabolism, to red cell 6-thioguanine nucleotides (6TGN), was studied in four patients with pemphigus vulgaris. Throughout treatment blood samples were taken for red cell 6TGN assay and differential white cell counts. Metabolite steady-state occurred in three patients in 2, 2 and 4 months respectively. In the fourth patient red cell 6TGN concentrations increased slowly over 3 years. There was a significant negative correlation between 6TGN concentrations and the white blood cell count (rs = -0.92, P less than 0.0005) in this patient.
摘要
对4例寻常型天疱疮患者的硫唑嘌呤代谢情况进行了研究，测定其红细胞6-硫鸟嘌呤核苷酸（6TGN）水平。在整个治疗过程中，采集血样检测红细胞6TGN水平及白细胞分类计数。分别有3例患者在2个月、2个月和4个月时达到代谢物稳态。第4例患者的红细胞6TGN浓度在3年中缓慢上升。该患者6TGN浓度与白细胞计数之间存在显著负相关（rs = -0.92，P < 0.0005）。
相似文献
1
Metabolism of azathioprine to 6-thioguanine nucleotides in patients with pemphigus vulgaris.寻常型天疱疮患者中硫唑嘌呤向6-硫鸟嘌呤核苷酸的代谢
Br J Clin Pharmacol. 1987 Feb;23(2):229-33. doi: 10.1111/j.1365-2125.1987.tb03034.x.
2
Azathioprine metabolism in kidney transplant recipients.肾移植受者的硫唑嘌呤代谢
Br J Clin Pharmacol. 1984 Nov;18(5):693-700. doi: 10.1111/j.1365-2125.1984.tb02531.x.
3
Thioguanine nucleotides and thiopurine methyltransferase in immunobullous diseases: optimal levels as adjunctive tools for azathioprine monitoring.免疫性大疱性疾病中的硫鸟嘌呤核苷酸和硫嘌呤甲基转移酶：作为硫唑嘌呤监测辅助工具的最佳水平
Arch Dermatol. 2009 Jun;145(6):644-52. doi: 10.1001/archdermatol.2009.81.
4
6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment.硫唑嘌呤治疗系统性结缔组织病期间红细胞中6-硫鸟嘌呤核苷酸的积累：一种可能的治疗监测指标。
Ann Rheum Dis. 1993 Feb;52(2):152-4. doi: 10.1136/ard.52.2.152.
5
Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood.测定血液中6-硫鸟嘌呤核苷酸和6-甲基巯基嘌呤核苷酸浓度的改进方法。
J Chromatogr B Biomed Sci Appl. 2001 Jun 5;757(1):1-9. doi: 10.1016/s0378-4347(00)00513-2.
6
Determination of Concentrations of Azathioprine Metabolites 6-Thioguanine and 6-Methylmercaptopurine in Whole Blood With the Use of Liquid Chromatography Combined With Mass Spectrometry.使用液相色谱-质谱联用技术测定全血中硫唑嘌呤代谢物6-硫鸟嘌呤和6-甲基巯基嘌呤的浓度
Transplant Proc. 2016 Jun;48(5):1836-9. doi: 10.1016/j.transproceed.2016.01.084.
7
Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease.利用红细胞6-硫鸟嘌呤代谢物水平优化炎症性肠病患者的硫唑嘌呤治疗。
Gut. 2001 May;48(5):642-6. doi: 10.1136/gut.48.5.642.
8
Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients.巯嘌呤甲基转移酶活性和巯嘌呤代谢物浓度不能预测巯嘌呤治疗的炎症性肠病患者的临床结局。
Aliment Pharmacol Ther. 2011 Sep;34(5):544-54. doi: 10.1111/j.1365-2036.2011.04756.x. Epub 2011 Jul 3.
9
Assay of an active metabolite of 6-thioguanine, 6-thioguanosine 5'-monophosphate, in human red blood cells.
J Chromatogr. 1982 Apr 16;229(1):121-7. doi: 10.1016/s0378-4347(00)86043-0.
10
Red blood cell anemia in a patient with pemphigus vulgaris induced by the use of mycophenolate mofetil and prednisone.
J Dermatolog Treat. 2007;18(4):243-5. doi: 10.1080/09546630701287324.
引用本文的文献
1
Utility of maternal 6-thioguanine nucleotide levels in predicting neonatal pancytopenia.母亲6-硫鸟嘌呤核苷酸水平在预测新生儿全血细胞减少症中的效用。
AJP Rep. 2013 May;3(1):25-8. doi: 10.1055/s-0032-1329683. Epub 2012 Dec 3.
2
Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations.低剂量别嘌醇足以优化炎症性肠病患者的巯嘌呤代谢物浓度不足的硫唑嘌呤治疗。
Eur J Clin Pharmacol. 2013 Aug;69(8):1521-31. doi: 10.1007/s00228-013-1500-1. Epub 2013 Apr 16.
3
Azathioprine in dermatology: a review in the light of advances in understanding methylation pharmacogenetics.硫唑嘌呤在皮肤病学中的应用：基于甲基化药物遗传学理解进展的综述
J R Soc Med. 1995 Mar;88(3):155P-160P.
4
Peliosis hepatis induced by 6-thioguanine administration.6-硫鸟嘌呤给药诱导的肝紫癜
Gut. 1988 Sep;29(9):1265-9. doi: 10.1136/gut.29.9.1265.
5
Pharmacogenetics of human erythrocyte thiopurine methyltransferase activity in a French population.法国人群中人类红细胞硫嘌呤甲基转移酶活性的药物遗传学
Br J Clin Pharmacol. 1991 Dec;32(6):729-34.
6
Pancytopenia related to azathioprine--an enzyme deficiency caused by a common genetic polymorphism: a review.与硫唑嘌呤相关的全血细胞减少症——一种由常见基因多态性引起的酶缺乏症：综述
J R Soc Med. 1992 Dec;85(12):752-6. doi: 10.1177/014107689208501213.
7
The clinical pharmacology of 6-mercaptopurine.6-巯基嘌呤的临床药理学。
Eur J Clin Pharmacol. 1992;43(4):329-39. doi: 10.1007/BF02220605.
本文引用的文献
1
Pemphigus: current concepts.天疱疮：当前概念
Ann Intern Med. 1980 Mar;92(3):396-405. doi: 10.7326/0003-4819-92-3-396.
2
Severe megaloblastic anaemia associated with abnormal azathioprine metabolism.与硫唑嘌呤代谢异常相关的严重巨幼细胞贫血。
Br J Clin Pharmacol. 1984 Feb;17(2):171-2. doi: 10.1111/j.1365-2125.1984.tb02333.x.
3
Treatment of pemphigus vulgaris. Results obtained in 84 patients between 1961 and 1982.寻常型天疱疮的治疗。1961年至1982年间84例患者的治疗结果。
Arch Dermatol. 1984 Jan;120(1):44-7. doi: 10.1001/archderm.120.1.44.
4
Azathioprine metabolism in kidney transplant recipients.肾移植受者的硫唑嘌呤代谢
Br J Clin Pharmacol. 1984 Nov;18(5):693-700. doi: 10.1111/j.1365-2125.1984.tb02531.x.
5
Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms.硫唑嘌呤和6-巯基嘌呤（6-MP）通过不同机制抑制人类混合淋巴细胞反应（MLR）。
Br J Clin Pharmacol. 1984 Apr;17(4):417-22. doi: 10.1111/j.1365-2125.1984.tb02366.x.
6
Effects of azathioprine on the human mixed lymphocyte reaction (MLR).硫唑嘌呤对人混合淋巴细胞反应（MLR）的影响。
Br J Clin Pharmacol. 1983 Feb;15(2):203-9. doi: 10.1111/j.1365-2125.1983.tb01487.x.
7
Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells.人红细胞中硫唑嘌呤、6-巯基嘌呤和6-硫鸟嘌呤的主要代谢产物6-硫鸟嘌呤核苷酸的测定
J Pharm Pharmacol. 1983 Jan;35(1):15-8. doi: 10.1111/j.2042-7158.1983.tb04255.x.
8
A biochemical mechanism for the delayed cytotoxic reaction of 6-mercaptopurine.6-巯基嘌呤延迟性细胞毒性反应的生化机制。
Cancer Res. 1974 Apr;34(4):738-46.
9
Serum immunosuppressive activity of azathioprine in normal subjects and patients with liver diseases.硫唑嘌呤在正常受试者和肝病患者中的血清免疫抑制活性。
Proc R Soc Med. 1972 Mar;65(3):260-3. doi: 10.1177/003591577206500316.
10
Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells.肾移植受者的皮肤癌与红细胞中6-硫鸟嘌呤核苷酸浓度升高有关。
Br J Dermatol. 1985 Dec;113(6):723-9. doi: 10.1111/j.1365-2133.1985.tb02408.x.
Zotero 插件