无金属硼烷催化的吡啶高对映选择性氢化反应。
Metal-free borane-catalyzed highly stereoselective hydrogenation of pyridines.
机构信息
Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
J Am Chem Soc. 2013 Sep 4;135(35):12968-71. doi: 10.1021/ja406761j. Epub 2013 Aug 19.
PMID:23944383
Abstract
A metal-free direct hydrogenation of pyridines was successfully realized by using homogeneous borane catalysts generated from alkenes and HB(C6F5)2 via in situ hydroboration. The reaction affords a broad range of piperidines in high yields with excellent cis stereoselectivities.
摘要
通过烯烃和 HB(C6F5)2 原位硼氢化反应生成的均相硼烷催化剂，成功实现了吡啶的无金属直接氢化。该反应以高产率和优异的顺式立体选择性得到了广泛的哌啶。
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