硼烷催化的2,7-二取代1,8-萘啶的无金属氢化反应
Borane-catalyzed metal-free hydrogenation of 2,7-disubstituted 1,8-naphthyridines.
作者信息
Wang Wei, Feng Xiangqing, Du Haifeng
机构信息
Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
Org Biomol Chem. 2016 Jul 12;14(28):6683-6. doi: 10.1039/c6ob01172a.
PMID:27334098
Abstract
Metal-free hydrogenation of 2,7-disubstituted 1,8-naphthyridines was successfully realized for the first time using in situ generated borane catalysts under mild conditions to furnish 1,2,3,4-tetrahydro-1,8-naphthyridine derivatives in 83-98% yields. Significantly, up to 74% ee was achieved for the corresponding asymmetric hydrogenation reactions.
摘要
首次在温和条件下使用原位生成的硼烷催化剂成功实现了2,7-二取代-1,8-萘啶的无金属氢化反应，以83%至98%的产率得到1,2,3,4-四氢-1,8-萘啶衍生物。值得注意的是，相应的不对称氢化反应的对映体过量率高达74%。
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