Donor and Transplantation Services, Canadian Blood Services, Ottawa, Ontario, Canada.
Transfusion. 2014 Mar;54(3 Pt 2):775-9. doi: 10.1111/trf.12380. Epub 2013 Aug 14.
The adequacy of communication and knowledge of donors and physicians regarding iron needs and the relationship between hemoglobin (Hb) and iron stores require evaluation to address donor iron deficiency.
A prospective cohort study was performed on 550 successful donors and 50 donors deferred for low Hb (<125 g/L on repeat fingerstick). Donors participated in an on-clinic interview and had serum ferritin measured. They were mailed their results and recontacted regarding follow-up.
Most donors are unaware of possible health impacts of donation and do not discuss donation with their physician. In successful donors, mean ferritin levels were 37 and 131 μg/L in first-time and reactivated (no donation for 2 years) females and males and 19 and 29 μg/L in frequent repeat females and males, respectively (p < 0.0001), with infrequent donors having intermediate results. Mean ferritin was 12 μg/L in donors deferred for low Hb. Twenty of 22 donors failing initial Hb testing and passing on repeat testing had ferritin below 25 μg/L. On follow-up, 63 of 164 donors (38%) with low ferritin were taking iron supplements 2 months postdonation.
Iron deficiency is frequent, particularly in female donors and frequent donors. A fail on initial Hb testing followed by a pass on repeat testing is likely to be due to iron deficiency and borderline anemia. Donors and physicians need to be more aware of iron needs associated with blood donation and appropriate treatment for low iron stores.
需要评估供者和医生在铁需求方面的沟通是否充分以及血红蛋白（Hb）和铁储备之间的关系，以解决供者铁缺乏的问题。
对 550 名成功供者和 50 名因 Hb 较低（手指重复检测<125g/L）而被推迟的供者进行前瞻性队列研究。供者参加了门诊访谈并检测了血清铁蛋白。将结果邮寄给他们，并就随访进行了重新联系。
大多数供者不知道献血可能对健康产生的影响，也没有与医生讨论过献血的问题。在成功的供者中，初次和再次激活（2 年内未献血）的女性和男性的平均铁蛋白水平分别为 37 和 131μg/L，频繁重复献血的女性和男性的平均铁蛋白水平分别为 19 和 29μg/L（p<0.0001），不频繁献血的供者则处于中间水平。Hb 较低而被推迟的供者的平均铁蛋白为 12μg/L。22 名初次 Hb 检测失败但重复检测通过的供者中有 20 人的铁蛋白低于 25μg/L。在随访中，164 名铁蛋白较低的供者中有 63 名（38%）在献血后 2 个月内服用了铁补充剂。
铁缺乏很常见，尤其是女性供者和频繁献血者。初次 Hb 检测失败后再次检测通过，很可能是由于铁缺乏和边缘性贫血。供者和医生需要更加了解与献血相关的铁需求以及缺铁储存的适当治疗方法。
