Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871 (P.R. China) http://en.coe.pku.edu.cn/faculty/faculty_143.htm.
Chem Asian J. 2013 Oct;8(10):2304-14. doi: 10.1002/asia.201300630. Epub 2013 Aug 15.
High spatiotemporal resolution interfaces between electrical sensors and biological systems, from single live cells to tissues, is crucial for many areas, including fundamental biophysical studies as well as medical monitoring and intervention. Herein, we summarize recent progress in the development and application of novel nanoscale devices for intracellular electrical recording of action potentials and the effort of merging electronic and biological systems seamlessly in three dimensions by using macroporous nanoelectronic scaffolds. The uniqueness of these nanoscale devices for minimally invasive, large-scale, high spatial resolution, and three-dimensional neural activity mapping are highlighted.
高时空分辨率的电传感器与生物系统之间的界面，从单个活细胞到组织，对于许多领域都是至关重要的，包括基础生物物理研究以及医疗监测和干预。本文总结了新型纳米器件在动作电位的细胞内电记录方面的开发和应用方面的最新进展，以及通过使用多孔纳米电子支架实现电子和生物系统在三维空间中无缝融合的努力。这些纳米器件在微创、大规模、高空间分辨率和三维神经活动测绘方面的独特性得到了强调。
