Cui Li, Sun E, Qian Qian, Fan Hong-Wei, Zou Jian-Jun, Jia Xiao-Bin
Key Laboratory of Drug Delivery System of Chinese Meteria Medica under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China.
Zhongguo Zhong Yao Za Zhi. 2013 May;38(10):1614-7.
To study different impacts of crude epimedium and extracts from different processed epimedium on pharmacokinetic characteristic parameters in mice. To explore the rationality of its processed products, mice were orally administered with crude epimedium and extracting solutions from heated epimedium and processed epimedium. With increased SOD value as an indicator, the relationship between time and equivalent body dose was obtained by using the pharmacological effect method. DAS 2.0 software was adopted to compare their pharmacokinetic parameters. The results showed significant differences in such pharmacokinetic parameters as Cmax and AUC of processed epimedium, heated epimedium and crude epimedium, namely processed epimedium > heated epimedium > crude epimedium. We could come to the conclusion that heated epimedium showed increased bioavailability, while epimedium processed with sheep oil could further promote in vivo absorption.
研究淫羊藿生品及不同炮制品提取物对小鼠药代动力学特征参数的影响。为探讨其炮制品的合理性，将小鼠分别灌胃给予淫羊藿生品、酒炙淫羊藿及羊脂炙淫羊藿提取液。以超氧化物歧化酶（SOD）值升高为指标，采用药理效应法得到时间与等效剂量的关系。采用DAS 2.0软件比较其药代动力学参数。结果表明，淫羊藿炮制品、酒炙淫羊藿及淫羊藿生品的药代动力学参数如Cmax和AUC存在显著差异，即羊脂炙淫羊藿＞酒炙淫羊藿＞淫羊藿生品。由此得出结论，酒炙淫羊藿的生物利用度提高，而羊脂炙淫羊藿可进一步促进其体内吸收。
