Meng Qing-Bo, Yin Yi-Xin, Zhang De-Zheng, Yang Guo-Ping
School of Automation, University of Science and Technology, Beijing 100083, China.
Zhongguo Zhong Yao Za Zhi. 2013 May;38(10):1631-42.
To raise the syndrome sequence quantification, differentiation and classification algorithm based on data envelopment analysis for solving the modeling issue of syndrome differentiation and classification of traditional Chinese medicine (TCM). This algorithm has three steps: first, in order to obtain basic units for explaining pathogenesis, and establish a syndrome collection on this basis mechanisms of syndrome differentiation and classification were analyzed and classified according to TCM theory, mechanisms of syndrome differentiation and classification were analyzed and classified according to TCM theory; second, regularity and syndromes of corresponding prescriptions were sought according to the incidence and development progress of syndromes, and mathematical tools of data envelopment analysis were used to calculate state data of syndromes in each stage and obtain quantitative syndrome sequence; finally, syndrome sequence was taken as the measurement standard to quantify candidate syndromes and diagnostic information, and the similarity was calculated to obtain the matching degree between diagnostic information and candidate syndromes, so as to complete the syndrome differentiation and classification calculation. According to the results of model-based reasoning, the algorithm could indicate the regularity implied in prescription materials, and grasp the dynamic process of syndromes in an all-round way, and its results were verified through calculation and analysis on clinical cases. At least, it provides an idea for quantitative modeling of TCM.
为提高基于数据包络分析的证型序列量化、鉴别与分类算法,以解决中医辨证论治的建模问题。该算法有三个步骤:首先,为获得解释发病机制的基本单元,并在此基础上建立证型集合,依据中医理论对辨证论治机制进行分析与分类;其次,根据证型的发生发展进程寻找相应方剂的规律和证型,运用数据包络分析的数学工具计算各阶段证型的状态数据,得到量化的证型序列;最后,以证型序列为度量标准对候选证型和诊断信息进行量化,计算相似度以获得诊断信息与候选证型之间的匹配度,从而完成辨证分类计算。根据基于模型推理的结果,该算法能够揭示方剂用药中隐含的规律,全面把握证型的动态过程,其结果通过临床病例的计算分析得到验证。至少,它为中医定量建模提供了一种思路。