Department of Chemical Engineering, Rowan University, Glassboro, NJ 08028, USA.
J Environ Sci Health A Tox Hazard Subst Environ Eng. 2013;48(13):1602-8. doi: 10.1080/10934529.2013.815080.
The life cycle emissions associated with the reduction of wastes from an adsorption process to remove palladium complexes in drug manufacture have been evaluated. The study assessed a green improvement to a process step in an active pharmaceutical ingredient synthesis where palladium catalyst is removed from a reaction mixture. The greener process uses a continuous adsorption system, composed of a more efficient adsorbent, consuming less organic solvent and rinse water, which results in less waste disposal. The newer process is also more energy and cost efficient from an operational perspective. There is a 94% reduction in the carbon footprint of the new process when compared to the current operation.
已评估了吸附工艺减少药物制造中钯络合物废物过程中相关的生命周期排放。本研究评估了活性药物成分合成中钯催化剂从反应混合物中去除的工艺步骤的绿色改进。更环保的工艺使用连续吸附系统，由更高效的吸附剂组成，消耗更少的有机溶剂和冲洗水，从而减少废物处置。从运营角度来看，新工艺在能源和成本方面也更具效率。与当前操作相比，新工艺的碳足迹减少了 94%。
