Department of Neurosurgery, The Military General Hospital of PLA, Beijing 100007, China; Department of Cell Transplantation, General Hospital of The Chinese People's Armed Police Forces, Beijing 100039, China.
Brain Res. 2013 Oct 2;1533:73-9. doi: 10.1016/j.brainres.2013.08.016. Epub 2013 Aug 12.
Neuronal injuries have been a challenging problem for treatment, especially in the case of complete and chronic cervical spinal cord injury (SCI). Recently, particular attention is paid to the potential of stem cell in treating SCI, but there are only few clinical studies and insufficient data. This study explored the efficacy of autologous bone marrow mesenchymal stem cells (BMMSCs) transplantation in the treatment of SCI. Forty patients with complete and chronic cervical SCI were selected and randomly assigned to one of the two experimental groups, treatment group and control group. The treatment group received BMMSCs transplantation to the area surrounding injury, while the control group was not treated with any cell transplantation. Both the transplant recipients and the control group were followed up to 6 months, postoperatively. Preoperative and postoperative neurological functions were evaluated with AIS grading, ASIA score, residual urine volume and neurophysiological examination. Results showed that in the treatment group 10 patients had a significant clinical improvement in terms of motor, light touch, pin prick sensory and residual urine volume, while nine patients showed changes in AIS grade. Neurophysiological examination was consistent with clinical observations. No sign of tumor was evident until 6 months postoperatively. In the control group, no improvement was observed in any of the neurological functions specified above. BMMSCs transplantation improves neurological function in patients with complete and chronic cervical SCI, providing valuable information on applications of BMMSCs for the treatment of SCI.
神经元损伤一直是治疗的难题，尤其是在完全性和慢性颈脊髓损伤（SCI）的情况下。最近，人们特别关注干细胞治疗 SCI 的潜力，但临床研究较少，数据不足。本研究探讨了自体骨髓间充质干细胞（BMMSCs）移植治疗 SCI 的疗效。选择了 40 例完全性和慢性颈 SCI 患者，并将其随机分为实验组和对照组。实验组接受 BMMSCs 移植到损伤周围区域，而对照组未进行任何细胞移植。两组移植受者均随访 6 个月。术前和术后采用 AIS 分级、ASIA 评分、残余尿量和神经生理学检查评估神经功能。结果显示，在治疗组中，10 例患者的运动、轻触觉、刺痛觉和残余尿量明显改善，9 例患者的 AIS 分级发生变化。神经生理学检查与临床观察一致。术后 6 个月未见肿瘤迹象。对照组上述任何神经功能均未见改善。BMMSCs 移植可改善完全性和慢性颈 SCI 患者的神经功能，为 BMMSCs 治疗 SCI 的应用提供了有价值的信息。
