Nguyen Michael, Yang Ester, Neelkantan Nikhil, Mikhaylova Alina, Arnold Raymond, Poudel Manoj K, Stewart Adam Michael, Kalueff Allan V
Department of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA 22908, USA; Thomas Jefferson High School for Science and Technology, 6560 Braddock Road, Alexandria, VA 22312, USA.
Behav Brain Res. 2013 Nov 1;256:172-87. doi: 10.1016/j.bbr.2013.08.012. Epub 2013 Aug 12.
Recently, the pathophysiological overlap between metabolic and mental disorders has received increased recognition. Zebrafish (Danio rerio) are rapidly becoming a popular model organism for translational biomedical research due to their genetic tractability, low cost, quick reproductive cycle, and ease of behavioral, pharmacological or genetic manipulation. High homology to mammalian physiology and the availability of well-developed assays also make the zebrafish an attractive organism for studying human disorders. Zebrafish neurobehavioral and endocrine phenotypes show promise for the use of zebrafish in studies of stress, obesity and related behavioral and metabolic disorders. Here, we discuss the parallels between zebrafish and other model species in stress and obesity physiology, as well as outline the available zebrafish models of weight gain, metabolic deficits, feeding, stress, anxiety and related behavioral disorders. Overall, zebrafish demonstrate a strong potential for modeling human behavioral and metabolic disorders, and their comorbidity.
最近，代谢紊乱和精神障碍之间的病理生理重叠已得到越来越多的认识。斑马鱼（Danio rerio）因其遗传易处理性、低成本、快速的繁殖周期以及行为、药理学或基因操作的简便性，正迅速成为转化生物医学研究中一种受欢迎的模式生物。与哺乳动物生理学的高度同源性以及完善的检测方法的可用性，也使斑马鱼成为研究人类疾病的有吸引力的生物体。斑马鱼的神经行为和内分泌表型显示出在应激、肥胖及相关行为和代谢紊乱研究中使用斑马鱼的前景。在此，我们讨论斑马鱼与其他模式物种在应激和肥胖生理学方面的相似之处，并概述现有的体重增加、代谢缺陷、摄食、应激、焦虑及相关行为障碍的斑马鱼模型。总体而言，斑马鱼在模拟人类行为和代谢紊乱及其共病方面显示出强大的潜力。
