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本文引用的文献

1
Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically.白细胞介素-11 是胃肠道肿瘤发生过程中主要的 IL-6 家族细胞因子，可作为治疗靶点。
Cancer Cell. 2013 Aug 12;24(2):257-71. doi: 10.1016/j.ccr.2013.06.017.
2
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer.微生物群诱导的上皮细胞白细胞介素 6 信号激活将炎性体驱动的炎症与可传播的癌症联系起来。
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9862-7. doi: 10.1073/pnas.1307575110. Epub 2013 May 21.
3
mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice.mTORC1 抑制限制了小鼠炎症相关的胃肠道肿瘤发生。
J Clin Invest. 2013 Feb;123(2):767-81. doi: 10.1172/JCI65086. Epub 2013 Jan 16.
4
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation.结直肠癌依赖于基质细胞中 TGF-β 驱动的程序进行转移起始。
Cancer Cell. 2012 Nov 13;22(5):571-84. doi: 10.1016/j.ccr.2012.08.013.
5
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.白细胞介素 22 结合蛋白受炎性体调控，并调节肠道肿瘤发生。
Nature. 2012 Nov 8;491(7423):259-63. doi: 10.1038/nature11535. Epub 2012 Oct 17.
6
STATs in cancer inflammation and immunity: a leading role for STAT3.信号转导和转录激活因子在癌症炎症与免疫中的作用：信号转导和转录激活因子3起主导作用
Nat Rev Cancer. 2009 Nov;9(11):798-809. doi: 10.1038/nrc2734.
7
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.白细胞介素-6（IL-6）和信号转导及转录激活因子3（Stat3）是肠道上皮细胞存活和结肠炎相关癌症发生所必需的。
Cancer Cell. 2009 Feb 3;15(2):103-13. doi: 10.1016/j.ccr.2009.01.001.
8
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.肠细胞中gp130介导的Stat3激活在结肠炎相关肿瘤发生过程中调节细胞存活和细胞周期进程。
Cancer Cell. 2009 Feb 3;15(2):91-102. doi: 10.1016/j.ccr.2009.01.002.
9
STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.信号转导和转录激活因子3（STAT3）和信号转导和转录激活因子1（STAT1）介导gp130受体突变小鼠中白细胞介素11（IL-11）依赖性及炎症相关的胃癌发生。
J Clin Invest. 2008 May;118(5):1727-38. doi: 10.1172/JCI34944.
10
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.转化生长因子-β通过抑制白细胞介素-6转信号传导来抑制结肠癌的肿瘤进展。
Immunity. 2004 Oct;21(4):491-501. doi: 10.1016/j.immuni.2004.07.020.

IL-11：IL-6 家族中突出的促肿瘤发生成员。

IL-11: a prominent pro-tumorigenic member of the IL-6 family.

机构信息

Cancer Prevention and Control Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA.

出版信息

Cancer Cell. 2013 Aug 12;24(2):145-7. doi: 10.1016/j.ccr.2013.07.018.

DOI:10.1016/j.ccr.2013.07.018
PMID:23948295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3855069/
Abstract

Cytokines have recently emerged as important players in tumor promotion and progression. In this issue of Cancer Cell, Putoczki and colleagues report the importance of interleukin 11 in a variety of gastrointestinal malignances and lay down a framework for its potential inhibition in a variety of human cancers.

摘要

细胞因子最近成为肿瘤促进和进展的重要参与者。在本期《癌细胞》中，Putoczki 及其同事报告了白细胞介素 11 在多种胃肠道恶性肿瘤中的重要性，并为其在多种人类癌症中的潜在抑制作用奠定了框架。