肿瘤坏死因子-α对慢性心力衰竭是敌是友？
Is tumor necrosis factor-α friend or foe for chronic heart failure?
机构信息
Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
出版信息
Circ Res. 2013 Aug 16;113(5):492-4. doi: 10.1161/CIRCRESAHA.113.302024.
Abstract
Although detrimental effects of tumor necrosis factor-α (TNF-α) have been reported in failing myocardium, clinical trials using TNF-α antagonists did not show the benefit of TNF-α inhibition in patients with chronic heart failure (CHF). The double-edged effects of TNF-α/Toll-like receptors (TLRs)-related proinflammatory cytokines and downstream signal transduction, nuclear factor (NF)-κB activation on failing myocardium are discussed.
摘要
虽然已经报道了肿瘤坏死因子-α（TNF-α）在衰竭心肌中的有害作用，但使用 TNF-α 拮抗剂的临床试验并未显示 TNF-α 抑制对慢性心力衰竭（CHF）患者的益处。TNF-α/Toll 样受体（TLRs）相关促炎细胞因子及其下游信号转导、核因子（NF）-κB 激活对衰竭心肌的双刃剑作用进行了讨论。
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