Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Dermatology. 2013;226(4):298-301. doi: 10.1159/000348708. Epub 2013 Aug 14.
Erythema papulatum centrifugum (EPC) was first described in 1962 by Watanabe [Jpn J Dermatol 1962;72:573] as eczematous lesions extending centrifugally. To date, more than 150 cases have been reported, but only in the Japanese literature. A review of the Japanese literature including our 5 new cases reveals that EPC occurs in middle-aged persons, predominantly in males, as a single lesion on the trunk that is self-limiting but recurs frequently. Although EPC shares several characteristics with the superficial type of erythema annulare centrifugum or asymmetrical periflexural exanthema, EPC differs from erythema annulare centrifugum in clinical manifestation, showing annular rings composed of grouped, tiny papules, and in the histology of perieccrine inflammation, while it differs from asymmetrical periflexural exanthema by male preponderance, onset age, high relapse rate and unique annular configuration. We discuss EPC as compared with other cutaneous disorders showing annular erythema or similar histopathology and suggest that EPC is a distinct clinical entity.
离心性环状红斑（EPC）于 1962 年由 Watanabe 首次描述[日本皮肤病学杂志 1962；72：573]，表现为离心性扩展的湿疹样病变。迄今为止，已有超过 150 例病例报告，但仅见于日语文献。对包括我们的 5 例新病例在内的日本文献进行复习表明，EPC 发生于中年人，以男性为主，病变单发于躯干，具有自限性但经常复发。尽管 EPC 在临床表现上与环状离心性红斑的浅表型或不对称性近侧肢端疹相似，但 EPC 在临床表现上与环状离心性红斑不同，表现为由成群的小丘疹组成的环状，在围汗腺炎的组织学上，而与不对称性近侧肢端疹不同的是男性患病率高、发病年龄、高复发率和独特的环状形态。我们讨论了 EPC 与表现为环状红斑或类似组织病理学的其他皮肤疾病的区别，并认为 EPC 是一种独特的临床实体。
