通过三氟甲硫酰胺与 2-(2-炔基)苯磺酰胺反应生成 4-((三氟甲基)硫代)-2H-苯并[e][1,2]噻嗪 1,1-二氧化物。
Generation of 4-((trifluoromethyl)thio)-2H-benzo[e][1,2]thiazine 1,1-dioxides via a reaction of trifluoromethanesulfanylamide with 2-(2-alkynyl)benzenesulfonamide.
机构信息
Key Laboratory of Functional Small Organic Molecules, Ministry of Education and College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China.
出版信息
Chem Commun (Camb). 2013 Oct 7;49(77):8647-9. doi: 10.1039/c3cc44263b.
PMID:23949253
Abstract
The incorporation of the (trifluoromethyl)thio group into the benzo[e][1,2]thiazine 1,1-dioxide scaffold via a reaction of trifluoromethanesulfanylamide with 2-(2-alkynyl)benzenesulfonamide is reported. The transformation proceeds under mild conditions to afford the 4-((trifluoromethyl)thio)-2H-benzo[e][1,2]thiazine 1,1-dioxides in moderate to good yields.
摘要
报道了通过三氟甲硫酰胺与 2-(2-炔基)苯磺酰胺反应，将（三氟甲基）硫基引入苯并[e][1,2]噻嗪 1,1-二氧化物骨架中的方法。该转化在温和条件下进行，以中等至良好的收率得到 4-((三氟甲基)硫基)-2H-苯并[e][1,2]噻嗪 1,1-二氧化物。
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