硅胶促进的2-炔基苯胺与异硫氰酸酯的串联加成-环化反应
Silica gel-promoted tandem addition-cyclization reactions of 2-alkynylbenzenamines with isothiocyanates.
作者信息
Ding Qiuping, Cao Banpeng, Zong Zhenzhen, Peng Yiyuan
机构信息
College of Chemistry and Chemical Engineering, Jiangxi Normal University, 99 Ziyang Road, Nanchang 330022, China.
出版信息
J Comb Chem. 2010 May 10;12(3):370-3. doi: 10.1021/cc100012a.
PMID:20334423
Abstract
Tandem addition-cyclization reactions of 2-alkynylbenzenamines with isothiocyanates promoted by silica gel are described. This reaction proceeds smoothly at 80 degrees C under metal- and solvent-free conditions, which provides an efficient and practical route for the generation of 2,4-dihydro-1H-benzo[d][1,3]thiazines. The recovered silica gel could be reused for several times.
摘要
描述了硅胶促进的2-炔基苯甲胺与异硫氰酸酯的串联加成-环化反应。该反应在80℃、无金属和无溶剂条件下顺利进行，为生成2,4-二氢-1H-苯并[d][1,3]噻嗪提供了一条高效实用的路线。回收的硅胶可重复使用多次。
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