正常体重和中度超重成年人肥胖特征中的共性与特异性
Commonality versus specificity among adiposity traits in normal-weight and moderately overweight adults.
作者信息
Raja G K, Sarzynski M A, Katzmarzyk P T, Johnson W D, Tchoukalova Y, Smith S R, Bouchard C
机构信息
1] Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA [2] Department of Biochemistry, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Punjab, Pakistan.
Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
出版信息
Int J Obes (Lond). 2014 May;38(5):719-23. doi: 10.1038/ijo.2013.153. Epub 2013 Aug 16.
BACKGROUND
Many adiposity traits have been related to health complications and premature death. These adiposity traits are intercorrelated but their underlying structure has not been extensively investigated. We report on the degree of commonality and specificity among multiple adiposity traits in normal-weight and moderately overweight adult males and females (mean body mass index (BMI)=22.9 kg m(-2), s.d.=2.4).
METHODS
A total of 75 healthy participants were assessed for a panel of adiposity traits including leg, arm, trunk, total fat masses and visceral adipose tissue (VAT) derived from dual energy X-ray absorptiometry (DXA), hepatic and muscle lipids from proton magnetic resonance spectroscopy, fat cell volume from an abdominal subcutaneous adipose tissue biopsy (n=36) and conventional anthropometry (BMI and waist girth). Spearman's correlations were calculated and were subjected to factor analysis.
RESULTS
Arm, leg, trunk and total fat masses correlated positively (r=0.78-0.95) with each other. VAT correlated weakly with fat mass indicators (r=0.24-0.31). Intrahepatic lipids (IHL) correlated weakly with all fat mass traits (r=0.09-0.34), whereas correlations between DXA depots and intramyocellular lipids (IMCL) were inconsequential. The four DXA fat mass measures, VAT, IHL and IMCL depots segregated as four independent factors that accounted for 96% of the overall adiposity variance. BMI and waist girth were moderately correlated with the arm, leg, trunk and total fat and weakly with VAT, IHL and IMCL.
CONCLUSION
Adiposity traits share a substantial degree of commonality, but there is considerable specificity across the adiposity variance space. For instance, VAT, IHL and IMCL are typically poorly correlated with each other and are poorly to weakly associated with the other adiposity traits. The same is true for BMI and waist girth, commonly used anthropometric indicators of adiposity. These results do not support the view that it will be possible to identify adequate anthropometric indicators of visceral, hepatic and muscle lipid content in normal-weight and moderately overweight individuals.
背景
许多肥胖特征都与健康并发症和过早死亡有关。这些肥胖特征相互关联，但其潜在结构尚未得到广泛研究。我们报告了正常体重和中度超重成年男性和女性（平均体重指数（BMI）=22.9 kg·m⁻²，标准差=2.4）多种肥胖特征之间的共性和特异性程度。
方法
对75名健康参与者进行了一系列肥胖特征评估，包括通过双能X线吸收法（DXA）得出的腿部、手臂、躯干、总脂肪量和内脏脂肪组织（VAT），通过质子磁共振波谱得出的肝脏和肌肉脂质，通过腹部皮下脂肪组织活检得出的脂肪细胞体积（n=36）以及传统人体测量指标（BMI和腰围）。计算了斯皮尔曼相关性，并进行了因子分析。
结果
手臂、腿部、躯干和总脂肪量彼此呈正相关（r=0.78 - 0.95）。VAT与脂肪量指标的相关性较弱（r=0.24 - 0.31）。肝内脂质（IHL）与所有脂肪量特征的相关性较弱（r=0.09 - 0.34），而DXA测量部位与肌细胞内脂质（IMCL）之间的相关性不显著。四个DXA脂肪量测量指标、VAT、IHL和IMCL测量部位分为四个独立因子，占总体肥胖差异的96%。BMI和腰围与手臂、腿部、躯干和总脂肪量呈中度相关，与VAT、IHL和IMCL呈弱相关。
结论
肥胖特征具有相当程度的共性，但在肥胖差异空间中存在相当大的特异性。例如，VAT、IHL和IMCL通常彼此相关性较差，与其他肥胖特征的相关性也较弱或较差。BMI和腰围这两个常用的肥胖人体测量指标也是如此。这些结果不支持这样一种观点，即有可能在正常体重和中度超重个体中确定足够的人体测量指标来反映内脏、肝脏和肌肉脂质含量。
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