腰臀比和躯干到肢体脂肪（DXA）分别比青少年女孩的皮下脂肪更能替代 IMCL 和内脏脂肪。
Waist to hip ratio and trunk to extremity fat (DXA) are better surrogates for IMCL and for visceral fat respectively than for subcutaneous fat in adolescent girls.
机构信息
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
出版信息
Nutr Metab (Lond). 2010 Dec 9;7:86. doi: 10.1186/1743-7075-7-86.
BACKGROUND
Increased visceral adipose tissue (VAT) and intramyocellular lipids (IMCL) are associated with increased metabolic risk. Clinical and DXA body composition measures that are associated with VAT are generally even more strongly associated with subcutaneous adipose tissue (SAT) reflecting general adiposity, and thus are not specific for VAT. Measures more strongly associated with VAT than SAT (thus more specific for VAT), and predictors of IMCL have not been reported.
SUBJECTS/METHODS: We studied 30 girls 12-18 years; 15 obese, 15 normal-weight. The following were assessed: (1) anthropometric measures: waist circumference at the umbilicus and iliac crest (WC-UC and WC-IC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), (2) DXA measures: total fat, percent body fat (PBF), percent trunk fat (PTF), trunk-to-extremity fat ratio (TEFR), (3) MRI and 1H-MRS: VAT and SAT (L4-L5), soleus-IMCL.
RESULTS
Group as a whole: WC, trunk fat and PBF were more strongly associated with SAT than VAT; none were specific for VAT. In contrast, PTF and TEFR were more significantly associated with VAT (r = 0.83 and 0.81 respectively, p <0.0001 for both) than SAT (r = 0.77 and 0.75, p < 0.0001 for both). Strongest associations of S-IMCL were with WHR (r = 0.66, p = 0.0004). Subgroup analysis: In obese girls, WHR and WHtR were more strongly correlated with VAT (r = 0.62 and 0.82, p = 0.04 and 0.001) than SAT (r = 0.41 and 0.73, p not significant and 0.007), and for DXA measures, PTF and TEFR were more significantly associated with VAT (r = 0.70 and 0.72, p = 0.007 and 0.006) than SAT (r = 0.52 and 0.53, p = 0.07 and 0.06). In controls, PTF and TEFR were more strongly correlated with VAT (r = 0.79, p = 0.0004 for both) than SAT (r = 0.71 and 0.72, p = 0.003 for both). WHR was associated with IMCL in obese girls (r = 0.78, p = 0.008), but not controls.
CONCLUSION
Overall, WHR (anthropometry), and PTF and TEFR (DXA) are good surrogates for IMCL and for visceral fat respectively in adolescent girls.
背景
内脏脂肪组织（VAT）和肌内脂肪（IMCL）的增加与代谢风险的增加有关。与 VAT 相关的临床和 DXA 体成分测量值通常与皮下脂肪组织（SAT）的相关性更强，反映了总体肥胖程度，因此与 VAT 不具有特异性。与 SAT 相比，与 VAT 相关性更强（因此对 VAT 更具特异性）、且能预测 IMCL 的测量值尚未见报道。
受试者/方法：我们研究了 30 名 12-18 岁的女孩；15 名肥胖，15 名体重正常。评估了以下内容：（1）人体测量学指标：脐部和髂嵴处的腰围（WC-UC 和 WC-IC）、腰臀比（WHR）、腰高比（WHtR）；（2）DXA 测量值：总脂肪、体脂肪百分比（PBF）、躯干脂肪百分比（PTF）、躯干-四肢脂肪比（TEFR）；（3）MRI 和 1H-MRS：L4-L5 处的 VAT 和 SAT、比目鱼肌 IMCL。
结果
整体组：WC、躯干脂肪和 PBF 与 SAT 的相关性强于 VAT；没有任何一项与 VAT 具有特异性。相比之下，PTF 和 TEFR 与 VAT 的相关性（r = 0.83 和 0.81，均 p <0.0001）比 SAT 更强（r = 0.77 和 0.75，均 p <0.0001）。S-IMCL 与 WHR 的相关性最强（r = 0.66，p = 0.0004）。亚组分析：在肥胖女孩中，WHR 和 WHtR 与 VAT 的相关性（r = 0.62 和 0.82，p = 0.04 和 0.001）强于 SAT（r = 0.41 和 0.73，p 无显著差异和 0.007），而对于 DXA 测量值，PTF 和 TEFR 与 VAT 的相关性（r = 0.70 和 0.72，p = 0.007 和 0.006）强于 SAT（r = 0.52 和 0.53，p = 0.07 和 0.06）。在对照组中，PTF 和 TEFR 与 VAT 的相关性（r = 0.79，p = 0.0004）比 SAT（r = 0.71 和 0.72，p = 0.003）更强。WHR 与肥胖女孩的 IMCL 相关（r = 0.78，p = 0.008），但与对照组无关。
结论
总体而言，WHR（人体测量学）以及 PTF 和 TEFR（DXA）是青少年女孩中 IMCL 和内脏脂肪的良好替代指标。
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