Chan Wai, Smith Leann E, Greenberg Jan S, Hong Jinkuk, Mailick Marsha R
Wai Chan, Leann E. Smith, Jan S. Greenberg, Jinkuk Hong, and Marsha R. Mailick, University of Wisconsin, Madison, Waisman Center.
Am J Intellect Dev Disabil. 2017 Jan;122(1):11-24. doi: 10.1352/1944-7558-122.1.11.
The present investigation explored long-term relationships of behavioral symptoms of adolescents and adults with developmental disabilities with the mental health of their mothers. Fragile X premutation carrier mothers of an adolescent or adult child with fragile X syndrome (n = 95), and mothers of a grown child with autism (n = 213) were included. Behavioral symptoms at Time 1 were hypothesized to predict maternal depressive symptoms at Time 3 via maternal executive dysfunction at Time 2. Results provided support for the mediating pathway of executive dysfunction. Additionally, the association of behavioral symptoms with executive dysfunction differed across the two groups, suggesting that premutation carriers may be more susceptible to caregiving stress due to their genotype.
本研究探讨了发育障碍青少年和成人的行为症状与其母亲心理健康之间的长期关系。研究纳入了患有脆性X综合征的青少年或成年子女的脆性X前突变携带者母亲(n = 95),以及患有自闭症成年子女的母亲(n = 213)。研究假设,时间1的行为症状通过时间2的母亲执行功能障碍来预测时间3的母亲抑郁症状。结果为执行功能障碍的中介途径提供了支持。此外,两组行为症状与执行功能障碍之间的关联存在差异,这表明前突变携带者可能因其基因型而更容易受到照顾压力的影响。