Romanov V A, Bereshkova R V
Zh Mikrobiol Epidemiol Immunobiol. 1975 Jun(6):66-72.
Experiments were conducted on guinea pigs sensitized with the AK C-vaccine components. In intracardiac injection with smallpox vaccine there was shown a possibility of development of marked hemodynamic disturbances, of the inflammatory-dystrophic processes of irreversibel character, with a subsequent neuronophagia and demyelinization. Injection of smallpox vaccine into the circulation of intact guinea pigs was accompanied by development in the nervous system of insignificant circulatory disturbances and of the inflammatory dystrophic phenomena of reversible character. A method of immunofluorescence was used and the antigen of the vaccine virus was revealed in the neurons of the brain and the spinal cord of the sensitized and intact animals. Marked hemodynamic and insignificant inflammatory-dystrophic processes were revealed in the nervous system of a child which died of the post-vaccinal encephalitis; an antigen of the smallpox virus was found by the immunofluorescent method in the nerve cells and the vessels in various portions of the nervous system.
对用AK C疫苗成分致敏的豚鼠进行了实验。在心内注射天花疫苗时，显示出出现明显血液动力学紊乱、不可逆性炎症-营养不良过程的可能性，随后出现噬神经细胞现象和脱髓鞘。将天花疫苗注入未致敏豚鼠的循环系统时，神经系统会出现轻微的循环紊乱和可逆性炎症-营养不良现象。采用免疫荧光法，在致敏和未致敏动物的脑和脊髓神经元中发现了疫苗病毒抗原。在死于接种后脑炎的一名儿童的神经系统中发现了明显的血液动力学紊乱和轻微的炎症-营养不良过程；通过免疫荧光法在神经系统各部位的神经细胞和血管中发现了天花病毒抗原。
