Romanov V A, Gorshunova L P, Berezhkova R V
Zh Mikrobiol Epidemiol Immunobiol. 1981 Mar(3):29-31.
Experiments on guinea-pigs showed that 3 subcutaneous injections of adsorbed DPT vaccine resulted (on days 7-14 of the experiment) in the accumulation of cells, sensitized to brain extract, in the lymphoid tissue. The production of circulating anticerebral autoantibodies occurred, as revealed by the indirect immunofluorescent method, during the whole time of the experiment (35 days). On days 28-35 of the experiment cellular immune reaction to autologous erythrocytes was detected in the peripheral blood of the immunized animals. The intracardiac injection of smallpox vaccine to the animals resulted in the appearance of lymphoid cells, sensitized to brain extract, on days 3-7 of the experiment, as well as in the appearance of anticerebral autoantibodies, detected by immunofluorescence, which circulated in the blood for 28 days. Cellular immune reaction to autologous erythrocytes in the peripheral blood of the guinea-pigs immunized with smallpox vaccine was registered on days 3-28 of the experiment.
对豚鼠的实验表明，皮下注射3次吸附百白破疫苗后（在实验的第7 - 14天），淋巴组织中出现了对脑提取物致敏的细胞积累。如间接免疫荧光法所示，在整个实验期间（35天）都产生了循环抗脑自身抗体。在实验的第28 - 35天，在免疫动物的外周血中检测到对自身红细胞的细胞免疫反应。对动物进行心内注射天花疫苗后，在实验的第3 - 7天出现了对脑提取物致敏的淋巴细胞，同时通过免疫荧光检测到抗脑自身抗体的出现，这些抗体在血液中循环了28天。在用天花疫苗免疫的豚鼠外周血中，在实验的第3 - 28天记录到了对自身红细胞的细胞免疫反应。
