Romanov V A, Gorshunova L P
Zh Mikrobiol Epidemiol Immunobiol. 1977 Oct(10):80-3.
Subcutaneous sensitization of guinea pigs with -vaccine, and also an intracardiac injection of smallpox or measles vaccine induced production of brain autoantibodies, whereas subcutaneous or intradermal immunization of the animals with liver viral vaccines was not accompanied by the formation of autoantibodies and development of the pathological processes in the nervous system tissue. tthe greatest changes in the brain tissue in the form of circulatory disturbances and inflammatory-dystrophic phenomena in combination with high autoantibody titres in the blood were noted in intracardiac injection of smallpox vaccine and in subturbancessensitization with AK-Vaccine and the least (short-term circulatory disturbances, transitory signs of serous meningitis and neuron dystrophy against the background of low blood auto anitbody content)--in intracardiac injection of measles vaccine. Administration of live viral vaccines into the circulation of animals against the background of their sensitization with -vaccine led to reduction of blood autoantibody level coinciding in time with the periods of marked pathomorphological changes in the brain tissue.
用疫苗对豚鼠进行皮下致敏，以及心内注射天花或麻疹疫苗可诱导脑自身抗体的产生，而用肝病毒疫苗对动物进行皮下或皮内免疫则不会伴随自身抗体的形成以及神经组织病理过程的发展。在心内注射天花疫苗以及用AK疫苗进行皮下致敏时，脑组织出现了最显著的变化，表现为循环障碍和炎症 - 营养不良现象，同时血液中自身抗体滴度很高；而在心内注射麻疹疫苗时变化最小（短期循环障碍、浆液性脑膜炎和神经元营养不良的短暂迹象，且血液中自身抗体含量较低）。在动物用疫苗致敏的背景下，向其循环系统中注入活病毒疫苗会导致血液中自身抗体水平降低，且这与脑组织中明显的病理形态学变化时期在时间上相吻合。
