Satish Sarvepalli Venkata, Shetty Krishna Prasad, Kilaru Krishnarao, Bhargavi Puridi, Reddy E Srinivas, Bellutgi Aditya
Department of Conservative Dentistry and Endodontics, Navodaya Dental College and Hospital, Raichur, India.
J Endod. 2013 Sep;39(9):1116-8. doi: 10.1016/j.joen.2012.11.049. Epub 2013 Jun 19.
The purpose of this study was to determine the anesthetic efficacy of lidocaine containing epinephrine compared with lidocaine containing epinephrine plus hyaluronidase (75 IU) when performing an inferior alveolar nerve block.
Patients complaining of pain in the mandibular posterior teeth were selected. Based on their chief complaint, proper clinical and radiographic examinations were performed. Among them, 40 subjects diagnosed with irreversible pulpitis were selected. The inferior alveolar nerve block was induced using 3 mL 2% lidocaine with epinephrine. Hyaluronidase (75 IU) or a placebo was injected 30 minutes after the beginning of pulpal anesthesia (randomized and double-blind trial). The duration of the effect in the pulpal and gingival tissues was evaluated by the response to painful electrical stimuli applied to the adjacent premolar and by mechanical stimuli (pinprick) to the buccal gingiva, respectively.
In both pulpal and gingival tissues, the duration of the anesthetic effects with hyaluronidase was longer than with placebo.
Hyaluronidase increased the duration of the effects of lidocaine in inferior alveolar nerve blocks.
本研究的目的是在进行下牙槽神经阻滞时，确定含肾上腺素的利多卡因与含肾上腺素加透明质酸酶（75国际单位）的利多卡因相比的麻醉效果。
选择主诉下颌后牙疼痛的患者。根据其主要症状进行适当的临床和影像学检查。其中，选取40例诊断为不可复性牙髓炎的受试者。使用3毫升含肾上腺素的2%利多卡因进行下牙槽神经阻滞。在牙髓麻醉开始30分钟后注射透明质酸酶（75国际单位）或安慰剂（随机双盲试验）。分别通过对相邻前磨牙施加疼痛电刺激的反应以及对颊侧牙龈的机械刺激（针刺）来评估牙髓和牙龈组织中的麻醉效果持续时间。
在牙髓和牙龈组织中，透明质酸酶组的麻醉效果持续时间均长于安慰剂组。
透明质酸酶可延长利多卡因在下牙槽神经阻滞中的作用持续时间。
