血常规作为系统性红斑狼疮临床和血清学活动度指标的实用性。
Usefulness of the hemogram as a measure of clinical and serological activity in systemic lupus erythematosus.
作者信息
Moreno-Torres Víctor, Castejón Raquel, Mellor-Pita Susana, Tutor-Ureta Pablo, Durán-Del Campo Pedro, Martínez-Urbistondo María, Vázquez-Comendador José, Gutierrez-Rojas Ángela, Rosado Silvia, Vargas-Nuñez Juan A
机构信息
Systemic Autoimmune Diseases Unit, Internal Medicine Service, IDIPHIM (University Hospital Puerta de Hierro Research Institute), Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
Medicine Department, School of Medicine. Universidad Autónoma de Madrid, Madrid, Spain.
出版信息
J Transl Autoimmun. 2022 May 13;5:100157. doi: 10.1016/j.jtauto.2022.100157. eCollection 2022.
BACKGROUND AND OBJECTIVES
Systemic Lupus Erythematosus (SLE) follow-up is based on clinical, and analytical parameters. We aimed to determine the differences between the Neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR) and Red blood cell distribution width (RDW) between SLE patients and healthy controls and to assess their association with anemia status, classical inflammatory biomarkers and cytokines, disease activity, SLE related factors and treatment received for SLE.
METHODS
Seventy-seven patients with SLE according to 2012 SLICC criteria and 80 healthy controls were included. Patients with SLE were classified in SLE with anemia (SLE-a) and SLE without anemia (SLE-na). Statistical analysis between SLE patients and controls and the association of serological and clinical activity markers with proposed hematological indices among SLE patients were performed.
RESULTS
RDW, NLR and PLR, were significantly higher in SLE patients than in healthy control group (p < 0.001), in SLE-a patients as compared to SLE-na (p < 0.0001) and were significantly associated with hypocomplementemia (p < 0.05). PLR was higher in active patients measured by SLEDAI-2K score and with longer disease duration (p < 0.05). RDW was associated with serological activity of the patients (p < 0.05) and was correlated with SLEDAI-2K and SLICC/ACR scores, hsCRP, D-dimer, fibrinogen, IL-6 and TNF as well as with corticosteroids intake (p = 0.05). A logistic regression analysis confirmed that after adjustment by age and hemoglobin values, RDW presented linear correlation with IL-6 levels (Beta-coefficient = 0.369, p = 0.003).
CONCLUSION
NLR, PLR and RDW values suggest SLE serological and clinical activity. Given their availability, these markers not only could be useful tools to identify and monitor active SLE patients but whose application should be considered in inflammatory pathologies orchestrated by IL-6 and TNF.
背景与目的
系统性红斑狼疮（SLE）的随访基于临床和分析参数。我们旨在确定SLE患者与健康对照者之间的中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和红细胞分布宽度（RDW）的差异，并评估它们与贫血状态、经典炎症生物标志物和细胞因子、疾病活动度、SLE相关因素以及SLE治疗的相关性。
方法
纳入77例符合2012年SLICC标准的SLE患者和80例健康对照者。SLE患者分为伴有贫血的SLE（SLE-a）和不伴有贫血的SLE（SLE-na）。对SLE患者与对照者进行统计分析，并对SLE患者中血清学和临床活动标志物与所提出的血液学指标的相关性进行分析。
结果
SLE患者的RDW、NLR和PLR显著高于健康对照组（p < 0.001），SLE-a患者高于SLE-na患者（p < 0.0001），且与低补体血症显著相关（p < 0.05）。根据SLEDAI-2K评分，活动期患者的PLR较高，且疾病持续时间较长（p < 0.05）。RDW与患者的血清学活动度相关（p < 0.05），并与SLEDAI-2K和SLICC/ACR评分、hsCRP、D-二聚体、纤维蛋白原、IL-6和TNF以及皮质类固醇摄入量相关（p = 0.05）。逻辑回归分析证实，在调整年龄和血红蛋白值后，RDW与IL-6水平呈线性相关（β系数 = 0.369，p = 0.003）。
结论
NLR、PLR和RDW值提示SLE的血清学和临床活动度。鉴于其可用性，这些标志物不仅可能是识别和监测活动期SLE患者的有用工具，而且在由IL-6和TNF介导的炎症性疾病中应考虑应用它们。
Zotero 插件