Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan, Gyeonggi-do, 425-707, Korea.
Dig Dis Sci. 2013 Nov;58(11):3263-9. doi: 10.1007/s10620-013-2824-5. Epub 2013 Aug 17.
Since colorectal adenoma or cancer is commonly associated with gastric adenoma or cancer, early colorectal adenoma detection can affect the survival of gastric adenoma or cancer patients.
The purpose here was to investigate the colorectal adenoma or cancer prevalence and evaluate the necessity for screening colonoscopy in gastric adenoma or cancer patients.
From September 2005 through August 2010, 857 patients younger than 70 years who had gastric adenoma or cancer were enrolled. Healthy age- and sex-matched controls were selected from the general screening population. The prevalence and risk of colorectal adenoma or cancer were compared between the participants and the controls.
Data from 416 patients in the gastric neoplasm group (123 with gastric adenoma and 293 with gastric cancer) and 416 healthy control group participants were included in the statistical analysis. The presence of gastric adenoma or cancer was an independent risk factor for colorectal neoplasm (OR = 1.348, 95 % CI = 1.001-1.815). Patients with diffuse type gastric cancer had a lower prevalence of colorectal adenoma or cancer than those with gastric adenoma or intestinal type cancer. In gastric cancer patients younger than 50 years, intestinal type histology was significantly associated with colorectal adenoma or cancer (OR = 3.838, 95 % CI = 1.077-13.677).
The colorectal adenoma or cancer risk was significantly increased in patients with gastric adenoma or cancer. Therefore, screening colonoscopy should be considered for gastric adenoma or cancer patients including young patients, in the case of intestinal type gastric cancer.
由于结直肠腺瘤或癌常与胃腺瘤或癌相关，因此早期结直肠腺瘤的检测可以影响胃腺瘤或癌患者的生存。
本研究旨在调查胃腺瘤或癌患者结直肠腺瘤或癌的患病率，并评估胃腺瘤或癌患者筛查结肠镜检查的必要性。
从 2005 年 9 月至 2010 年 8 月，共纳入了 857 例年龄小于 70 岁的胃腺瘤或癌患者。从一般筛查人群中选择了年龄和性别匹配的健康对照。比较了参与者和对照组之间结直肠腺瘤或癌的患病率和风险。
在胃肿瘤组（123 例胃腺瘤和 293 例胃癌）的 416 例患者和 416 例健康对照组参与者中，有 416 例患者的数据纳入了统计分析。胃腺瘤或癌的存在是结直肠肿瘤的独立危险因素（OR=1.348，95%CI=1.001-1.815）。弥漫型胃癌患者的结直肠腺瘤或癌患病率低于胃腺瘤或肠型胃癌患者。在年龄小于 50 岁的胃癌患者中，肠型组织学与结直肠腺瘤或癌显著相关（OR=3.838，95%CI=1.077-13.677）。
胃腺瘤或癌患者的结直肠腺瘤或癌风险显著增加。因此，对于胃腺瘤或癌患者，包括年轻患者，如有肠型胃癌，应考虑进行结肠镜筛查。
