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整合E-钙黏蛋白表达水平与TNM分期以增强对结直肠癌患者的预后预测。

Integrating E-cadherin expression levels with TNM staging for enhanced prognostic prediction in colorectal cancer patients.

作者信息

Lee Jae-Ghi, Park Ilkyu, Lee Hannah, Nam Seungyoon, Kim Jisup, Lee Won-Suk, Kang Myunghee, Kim Jung Ho

机构信息

Gachon Medical Research Institute, Gachon Biomedical Convergence Institute, College of Medicine, Gachon University Gil Medical Center, Gachon University, Incheon, 21565, Republic of Korea.

Department of Internal Medicine, College of Medicine, Gachon University Gil Medical Center, Gachon University, Incheon, 21565, Republic of Korea.

出版信息

BMC Cancer. 2025 Jan 27;25(1):150. doi: 10.1186/s12885-025-13539-9.

DOI:10.1186/s12885-025-13539-9
PMID:39871234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11770905/
Abstract

PURPOSE

This study aimed to investigate the clinical significance of E-cadherin expression levels in colorectal cancer tissues and explore the relationship between E-cadherin expression and tumor node metastasis (TNM) stage. The goal was to establish a more accurate prognostic prediction for colorectal cancer patients by analyzing E-cadherin expression levels alongside TNM staging.

METHODS

The study examined colorectal cancer patients by dividing them into groups based on E-cadherin expression levels. It then assessed their 5-year event-free survival (EFS) and disease-specific survival (DSS) hazard ratios (HRs). Additionally, the prognosis of patients was analyzed by combining E-cadherin expression levels with TNM staging, particularly focusing on patients in stages III and IV.

RESULTS

The E-cadherin group had significantly worse outcomes, with HRs of 2.30 for EFS and 2.76 for DSS compared to the E-cadherin group. When combined with TNM stage III/IV, patients with E-cadherin expression showed a poor prognosis, with HRs of 1.93 for EFS and 2.35 for DSS compared to those with E-cadherin expression at the same TNM stage.

CONCLUSIONS

Low levels of E-cadherin expression are associated with a poor prognosis and decreased survival in colorectal cancer patients. Combining E-cadherin expression levels with TNM staging provides a more precise prediction of patient prognosis and survival, potentially guiding personalized treatment strategies.

摘要

目的

本研究旨在探讨E-钙黏蛋白在结直肠癌组织中的表达水平的临床意义，并探究E-钙黏蛋白表达与肿瘤淋巴结转移（TNM）分期之间的关系。目标是通过分析E-钙黏蛋白表达水平并结合TNM分期，为结直肠癌患者建立更准确的预后预测。

方法

该研究根据E-钙黏蛋白表达水平将结直肠癌患者分组进行检查。然后评估他们的5年无事件生存期（EFS）和疾病特异性生存期（DSS）的风险比（HRs）。此外，通过将E-钙黏蛋白表达水平与TNM分期相结合来分析患者的预后，尤其关注III期和IV期患者。

结果

与E-钙黏蛋白表达正常组相比，E-钙黏蛋白低表达组的预后明显更差，EFS的HR为2.30，DSS的HR为2.76。当与TNM III/IV期相结合时，E-钙黏蛋白表达的患者预后较差，与处于相同TNM分期但E-钙黏蛋白正常表达的患者相比，EFS的HR为1.93，DSS的HR为2.35。

结论

E-钙黏蛋白低表达与结直肠癌患者的预后不良和生存期缩短相关。将E-钙黏蛋白表达水平与TNM分期相结合可更精确地预测患者的预后和生存期，可能为个性化治疗策略提供指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/0d236626445f/12885_2025_13539_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/6dae07d6541e/12885_2025_13539_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/6f188db4b307/12885_2025_13539_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/6da0fb879225/12885_2025_13539_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/ed8ca91d3997/12885_2025_13539_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/0d236626445f/12885_2025_13539_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/6dae07d6541e/12885_2025_13539_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/6f188db4b307/12885_2025_13539_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/6da0fb879225/12885_2025_13539_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/ed8ca91d3997/12885_2025_13539_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/758e/11770905/0d236626445f/12885_2025_13539_Fig5_HTML.jpg

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