Division of Stem Cell Therapy (Endowed Chair by ANGFA Co.), St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, 216-8511, Japan,
Arch Dermatol Res. 2013 Oct;305(8):755-61. doi: 10.1007/s00403-013-1403-0. Epub 2013 Aug 18.
It is known that baldness caused by androgenetic alopecia is involved with androgen and the androgen receptor. Furthermore, it has been reported that testosterone secretion follows a circadian rhythm. Therefore, we hypothesized that a relationship exists between androgen-induced alopecia and biological rhythm. The mammalian circadian rhythm is controlled by several clock genes. Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 (BMAL1), one of the clock genes, is a transcription factor that plays central roles in the regulation of circadian rhythms. In this study, we investigated the influence of BMAL1 on hair follicle functions and hair growth. Mice deficient in BMAL1 expression exhibited a delay in hair regrowth after shaving. In hair follicles of mouse vibrissa, expression of Bmal1 and other clock genes was found to be rhythmic. Knockdown of BMAL1 in human follicle dermal papilla cells resulted in modulation of expression of several hair growth-related genes. Therefore, we concluded that expression of clock genes in hair follicles is linked to the circadian rhythm and that BMAL1 can regulate hair growth.
已知雄激素性脱发是与雄激素和雄激素受体有关的。此外，据报道，睾丸酮分泌存在昼夜节律。因此，我们假设雄激素性脱发与生物节律之间存在关系。哺乳动物的昼夜节律受几个生物钟基因控制。生物钟基因之一的脑和肌肉芳香烃受体核转位蛋白样蛋白 1（BMAL1）是一种转录因子，在调节昼夜节律中起着核心作用。在这项研究中，我们研究了 BMAL1 对毛囊功能和毛发生长的影响。缺乏 BMAL1 表达的小鼠在剃须后毛发再生延迟。在小鼠触须毛囊中，发现 Bmal1 和其他生物钟基因的表达具有节律性。在人毛囊真皮乳头细胞中敲低 BMAL1 导致几个与毛发生长相关的基因表达发生变化。因此，我们得出结论，毛囊中时钟基因的表达与昼夜节律有关，并且 BMAL1 可以调节毛发生长。
