医源性精子遗传损伤。
Iatrogenic genetic damage of spermatozoa.
机构信息
Division of Urology, Department of Surgery, McGill University and the Research Institute- McGill University Health Centre, Royal Victoria Hospital, room H6.46, 687 Avenue des Pins Ouest, Montréal, Québec, H3A 1A1, Canada,
出版信息
Adv Exp Med Biol. 2014;791:117-35. doi: 10.1007/978-1-4614-7783-9_8.
Various factors that negatively influence male fertility can affect sperm morphology and physiology. Many studies on humans and animals suggest that both radiation and chemotherapy alter the sperm chromatin, inducing significant damage to sperm DNA, and decrease the level of protamination, thereby altering DNA compaction. Spermatozoa from cancer survivors are affected by chemotherapy even years after the end of treatment. We are exposed to various toxicants present in the environment (e.g., products of air pollution, pesticides, and plasticizers) whose impact on human male reproduction has not yet been established.This chapter aims to update our knowledge on how the sperm chromatin structure is modified by external agents and to describe the different strategies available to better study this complex structure in infertile men.
各种负面因素会影响男性生育能力，从而影响精子形态和生理机能。许多关于人类和动物的研究表明，辐射和化疗都会改变精子染色质，导致精子 DNA 严重受损，并降低鱼精蛋白水平，从而改变 DNA 的紧密程度。即使在治疗结束多年后，癌症幸存者的精子仍会受到化疗的影响。我们会接触到环境中存在的各种有毒物质（例如，空气污染、农药和增塑剂的产物），但其对人类男性生殖的影响尚未确定。本章旨在更新我们对外部因素如何改变精子染色质结构的认识，并描述可用的不同策略，以便更好地研究不育男性的这种复杂结构。
Zotero 插件