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Some relevant points on sperm DNA fragmentation tests.关于精子DNA碎片化检测的一些相关要点。
Transl Androl Urol. 2017 Sep;6(Suppl 4):S560-S563. doi: 10.21037/tau.2017.03.47.
2
Sperm DNA damage: how relevant is it clinically?精子 DNA 损伤：临床相关性如何？
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Inter-and Intra-Laboratory Standardization of TUNEL Assay for Assessment of Sperm DNA Fragmentation.用于评估精子DNA碎片化的TUNEL检测法的实验室间和实验室内标准化
Curr Protoc Toxicol. 2017 Nov 8;74:16.11.1-16.11.22. doi: 10.1002/cptx.37.
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Should we evaluate and treat sperm DNA fragmentation?我们应该评估并治疗精子DNA碎片化吗？
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Diagnostics of DNA fragmentation in human spermatozoa: Are sperm chromatin structure analysis and sperm chromatin dispersion tests (SCD-HaloSpermG2 ) comparable?人类精子 DNA 碎片化的诊断：精子染色质结构分析和精子染色质扩散试验（SCD-HaloSpermG2）是否具有可比性？
Andrologia. 2019 Sep;51(8):e13316. doi: 10.1111/and.13316. Epub 2019 May 17.
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Is sperm DNA fragmentation a useful test that identifies a treatable cause of male infertility?精子 DNA 碎片化检测是否可用于识别男性不育的可治疗病因？
Best Pract Res Clin Obstet Gynaecol. 2018 Nov;53:11-19. doi: 10.1016/j.bpobgyn.2018.09.003. Epub 2018 Sep 29.
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Sperm DNA Fragmentation: Consequences for Reproduction.精子 DNA 碎片化：对生殖的影响。
Adv Exp Med Biol. 2019;1166:87-105. doi: 10.1007/978-3-030-21664-1_6.
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Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis.测量精子DNA碎片化与辅助生殖的临床结局：一项系统评价和荟萃分析
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Decreased activity of superoxide dismutase in the seminal plasma of infertile men correlates with increased sperm deoxyribonucleic acid fragmentation during the first hours after sperm donation.不育男性精液中超氧化物歧化酶活性降低与精子捐献后最初几小时内精子脱氧核糖核酸片段化增加相关。
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The Sperm Chromatin Structure Assay (SCSA(®)) and other sperm DNA fragmentation tests for evaluation of sperm nuclear DNA integrity as related to fertility.精子染色质结构分析（SCSA(®)）及其他用于评估与生育力相关的精子核DNA完整性的精子DNA碎片化检测。
Anim Reprod Sci. 2016 Jun;169:56-75. doi: 10.1016/j.anireprosci.2016.01.017. Epub 2016 Feb 17.

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1
High sperm DNA fragmentation - finding a needle in the haystack: tips on selecting the best sperm for ICSI and ART.高精子DNA碎片化——大海捞针：关于为卵胞浆内单精子注射和辅助生殖技术选择最佳精子的小贴士
Asian J Androl. 2025 Mar 1;27(2):139-143. doi: 10.4103/aja202451. Epub 2024 Sep 3.
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Cryopreservation of Human Spermatozoa: Functional, Molecular and Clinical Aspects.人类精子的冷冻保存：功能、分子和临床方面。
Int J Mol Sci. 2023 Feb 28;24(5):4656. doi: 10.3390/ijms24054656.
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Live birth must be the primary reproductive endpoint in IVF/ICSI studies evaluating sperm DNA fragmentation testing.在评估精子DNA片段化检测的体外受精/卵胞浆内单精子注射（IVF/ICSI）研究中，活产必须是主要的生殖终点。
Transl Androl Urol. 2017 Sep;6(Suppl 4):S564-S565. doi: 10.21037/tau.2017.04.34.
4
A Strengths-Weaknesses-Opportunities-Threats (SWOT) analysis on the clinical utility of sperm DNA fragmentation testing in specific male infertility scenarios.针对特定男性不育症情况中精子DNA碎片检测临床效用的优势-劣势-机会-威胁（SWOT）分析。
Transl Androl Urol. 2017 Sep;6(Suppl 4):S734-S760. doi: 10.21037/tau.2017.08.20.

本文引用的文献

1
Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios.精子DNA碎片检测的临床应用：基于临床场景的实践建议
Transl Androl Urol. 2016 Dec;5(6):935-950. doi: 10.21037/tau.2016.10.03.
2
Measuring Sperm DNA Fragmentation and Clinical Outcomes of Medically Assisted Reproduction: A Systematic Review and Meta-Analysis.测量精子DNA碎片化与辅助生殖的临床结局：一项系统评价和荟萃分析
PLoS One. 2016 Nov 10;11(11):e0165125. doi: 10.1371/journal.pone.0165125. eCollection 2016.
3
FSH treatment in infertile males candidate to assisted reproduction improved sperm DNA fragmentation and pregnancy rate.对候选辅助生殖的不育男性进行促卵泡激素（FSH）治疗可改善精子DNA碎片化程度并提高妊娠率。
Endocrine. 2017 May;56(2):416-425. doi: 10.1007/s12020-016-1037-z. Epub 2016 Jul 27.
4
A systematic review and meta-analysis to determine the effect of sperm DNA damage on fertilization and intracytoplasmic sperm injection outcome.一项系统评价和荟萃分析，以确定精子DNA损伤对受精及卵胞浆内单精子注射结局的影响。
Asian J Androl. 2017 Jan-Feb;19(1):80-90. doi: 10.4103/1008-682X.182822.
5
Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study.根据促卵泡激素（FSH）受体多态性p.N680S，用人重组FSH治疗可改善特发性不育男性的精子DNA片段化：一项药物遗传学研究。
Hum Reprod. 2016 Sep;31(9):1960-9. doi: 10.1093/humrep/dew167. Epub 2016 Jun 20.
6
Variation of DNA Fragmentation Levels During Density Gradient Sperm Selection for Assisted Reproduction Techniques: A Possible New Male Predictive Parameter of Pregnancy?辅助生殖技术中密度梯度精子筛选过程中DNA片段化水平的变化：一种可能的新的男性妊娠预测参数？
Medicine (Baltimore). 2016 May;95(20):e3624. doi: 10.1097/MD.0000000000003624.
7
DNA fragmentation in two cytometric sperm populations: relationship with clinical and ultrasound characteristics of the male genital tract.两种流式细胞术检测的精子群体中的DNA片段化：与男性生殖道临床及超声特征的关系
Asian J Androl. 2017 May-Jun;19(3):272-279. doi: 10.4103/1008-682X.174854.
8
Diagnostic accuracy of sperm DNA degradation index (DDSi) as a potential noninvasive biomarker to identify men with varicocele-associated infertility.精子DNA降解指数（DDSi）作为一种潜在的非侵入性生物标志物用于识别精索静脉曲张相关性不育男性的诊断准确性。
Int Urol Nephrol. 2015 Sep;47(9):1471-7. doi: 10.1007/s11255-015-1053-6. Epub 2015 Jul 31.
9
DNA fragmentation in brighter sperm predicts male fertility independently from age and semen parameters.精子发光度中的DNA碎片化独立于年龄和精液参数可预测男性生育能力。
Fertil Steril. 2015 Sep;104(3):582-90.e4. doi: 10.1016/j.fertnstert.2015.06.005. Epub 2015 Jul 4.
10
Investigation on the Origin of Sperm DNA Fragmentation: Role of Apoptosis, Immaturity and Oxidative Stress.精子DNA碎片化起源的研究：细胞凋亡、不成熟和氧化应激的作用
Mol Med. 2015 Jan 30;21(1):109-22. doi: 10.2119/molmed.2014.00158.

Some relevant points on sperm DNA fragmentation tests.

作者信息

Muratori Monica, Baldi Elisabetta

机构信息

Sexual Medicine and Andrology Unit, Department of Experimental, Clinical and Biomedical Sciences, University of Florence, Florence, Italy.

出版信息

Transl Androl Urol. 2017 Sep;6(Suppl 4):S560-S563. doi: 10.21037/tau.2017.03.47.

DOI:10.21037/tau.2017.03.47
PMID:29082178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5643625/
Abstract
摘要