London Fertility Associates, 104 Harley Street, London, UK,
Adv Exp Med Biol. 2014;791:173-89. doi: 10.1007/978-1-4614-7783-9_11.
According to worldwide statistics, between one in four and one in five couples have fertility problems. These problems are equally distributed between males and females. Modern lifestyle has obviously increased these problems: endocrine-disrupting chemicals, such as plastic polymer catalysts, alkylphenols, phthalates and so on, and cosmetic additives seem to be strongly involved in this fertility problem. Many of these compounds increase oxidative stress (OS) and thus impair spermatogenesis. The oocyte has only a finite capacity, decreasing with maternal age, to repair sperm-borne decays. To decrease this DNA repair burden, reducing the sperm DNA damages linked to OS is tempting. Antioxidant vitamins are often given haphazardly; they are not very efficient and potentially detrimental. A detailed analysis of the sperm nucleus is mandatory (DNA fragmentation or lack of nuclear condensation) prior to any treatment. Here we discuss new concepts in OS and the corresponding therapeutic approaches.
根据全球统计数据，每四到五对夫妇中就有一对存在生育问题。这些问题在男性和女性中分布均匀。现代生活方式显然增加了这些问题：内分泌干扰化学物质，如塑料聚合物催化剂、烷基酚、邻苯二甲酸酯等，以及化妆品添加剂，似乎与这一生育问题密切相关。这些化合物中的许多物质会增加氧化应激（OS），从而损害精子发生。卵母细胞修复精子携带的损伤的能力是有限的，随着母体年龄的增长而下降。为了减轻这种 DNA 修复负担，降低与 OS 相关的精子 DNA 损伤是很有吸引力的。抗氧化维生素通常是随意给予的；它们的效果不是很理想，而且可能有潜在的危害。在进行任何治疗之前，必须对精子核进行详细分析（DNA 碎片化或核浓缩缺乏）。在这里，我们讨论 OS 的新概念和相应的治疗方法。
