镉暴露与临床心血管疾病：系统综述。
Cadmium exposure and clinical cardiovascular disease: a systematic review.
机构信息
Fundacion de Investigacion del Hospital Clinico de Valencia-INCLIVA, Department of Medicine, School of Medicine, Avda. Blasco Ibáñez 15, 46010 Valencia, Spain.
出版信息
Curr Atheroscler Rep. 2013 Oct;15(10):356. doi: 10.1007/s11883-013-0356-2.
Abstract
Mounting evidence supports that cadmium, a toxic metal found in tobacco, air and food, is a cardiovascular risk factor. Our objective was to conduct a systematic review of epidemiologic studies evaluating the association between cadmium exposure and cardiovascular disease. Twelve studies were identified. Overall, the pooled relative risks (95% confidence interval) for cardiovascular disease, coronary heart disease, stroke, and peripheral arterial disease were: 1.36 (95% CI: 1.11, 1.66), 1.30 (95% CI: 1.12, 1.52), 1.18 (95% CI: 0.86, 1.59), and 1.49 (95% CI: 1.15, 1.92), respectively. The pooled relative risks for cardiovascular disease in men, women and never smokers were 1.29 (1.12, 1.48), 1.20 (0.92, 1.56) and 1.27 (0.97, 1.67), respectively. Together with experimental evidence, our review supports the association between cadmium exposure and cardiovascular disease, especially for coronary heart disease. The number of studies with stroke, heart failure (HF) and peripheral arterial disease (PAD) endpoints was small. More studies, especially studies evaluating incident endpoints, are needed.
摘要
越来越多的证据表明，镉是一种存在于烟草、空气和食物中的有毒金属，它是心血管疾病的一个风险因素。我们的目的是对评估镉暴露与心血管疾病之间关联的流行病学研究进行系统评价。确定了 12 项研究。总体而言，心血管疾病、冠心病、中风和外周动脉疾病的汇总相对风险（95%置信区间）分别为：1.36（95%CI：1.11，1.66）、1.30（95%CI：1.12，1.52）、1.18（95%CI：0.86，1.59）和 1.49（95%CI：1.15，1.92）。男性、女性和从不吸烟者的心血管疾病汇总相对风险分别为 1.29（1.12，1.48）、1.20（0.92，1.56）和 1.27（0.97，1.67）。结合实验证据，我们的综述支持镉暴露与心血管疾病之间的关联，特别是与冠心病的关联。具有中风、心力衰竭（HF）和外周动脉疾病（PAD）终点的研究数量较少。需要更多的研究，特别是评估发病终点的研究。
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