Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
Org Lett. 2013 Sep 6;15(17):4362-5. doi: 10.1021/ol4018694. Epub 2013 Aug 19.
A new route to trisubstituted olefins through a palladium-catalyzed alkyne insertion/reduction reaction with unactivated alkyl iodides is reported. The reaction proceeds under mild conditions and tolerates a range of functional groups and substitution patterns. Preliminary mechanistic inquiry suggests that the transformation may proceed through a hybrid radical/organometallic pathway.
本文报道了一种通过钯催化的炔烃插入/还原反应，从未活化的烷基碘化物合成三取代烯烃的新途径。该反应在温和的条件下进行，可耐受多种官能团和取代模式。初步的机理研究表明，该转化可能通过杂化自由基/有机金属途径进行。
