Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
J Am Chem Soc. 2011 Dec 21;133(50):20146-8. doi: 10.1021/ja2091883. Epub 2011 Nov 23.
A palladium-catalyzed Heck-type reaction of unactivated alkyl iodides is described. This process displays broad substrate scope with respect to both alkene and alkyl iodide components and provides efficient access to a variety of cyclic products. The reaction is proposed to proceed via a hybrid organometallic-radical mechanism, facilitating the Heck-type process with alkyl halide coupling partners. Initial intermolecular studies are also reported, demonstrating the potentially wide applicability of this approach in synthesis.
钯催化的未活化烷基碘的 Heck 型反应被描述。该过程对烯烃和烷基碘底物均具有广泛的底物范围，并提供了多种环状产物的有效合成途径。该反应被认为是通过杂合的有机金属-自由基机理进行的，这促进了与卤代烃偶联的 Heck 型反应。也报道了初步的分子间研究，证明了该方法在合成中具有广泛的潜在适用性。
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