Nejamkis M R, Nota N R, Weissenbacher M C, Guerrero L B, Giovanniello O A
Acta Virol. 1975 May;19(3):237-44.
Passive immunity, naturally acquired from immune mothers or artificially induced by the administration of homologous hyperimmune serum, conferred on suckling mice a high degree of resistance against infection with Junín virus. Maternal antibodies in the circulating blood of the young were not detectable in the first days after birth, but rised rapidly from the 8th to the 20th day of lactation. By cross-foster nursing experiments it was shown that the greater part of the transmission of passive immunity occurred after birth, although there was transmission of a significant, though small part, before birth. The virus passage from mothers to offspring was excluded, since Junín virus was not recovered from brains, livers, spleens and kidneys of uninfected young, born from infected mothers.
被动免疫，无论是从免疫的母体自然获得，还是通过注射同源超免疫血清人工诱导产生，都能使乳鼠对胡宁病毒感染具有高度抵抗力。幼鼠循环血液中的母体抗体在出生后的头几天无法检测到，但在哺乳期第8天到第20天迅速上升。通过交叉寄养实验表明，被动免疫的大部分传递发生在出生后，尽管在出生前也有一小部分显著的传递。由于未感染的幼鼠（其母亲为感染鼠）的脑、肝、脾和肾中未检测到胡宁病毒，所以排除了病毒从母体传给后代的情况。
