Nota N R, Nejamkis M R, Giovanniello O A
Acta Virol. 1976 Feb;20(1):61-5.
Rabbit anti-mouse thymocyte serum (ATS) administrated as late as 7 days after infection suppressed host cell-mediated responsiveness to intracerebrally injected Junín virus, thereby diminishing the morbility and mortality of this infection. It did not affect either the humoral antibody response or the virus titer in brain. This findings suggest that: a) in mouse brain cells, Junín virus infection is basically non-cytopathic: b) cell-mediated immunity is responsible for morbility and mortality and does not clear up virus from brain as in other viral encephalitides; and c) ATS may be of therapeutic interest by suppressing or diminishing the cell-mediated response to Junín virus.
感染后7天给予兔抗小鼠胸腺细胞血清（ATS）可抑制宿主细胞介导的对脑内注射胡宁病毒的反应性，从而降低该感染的发病率和死亡率。它对体液抗体反应或脑内病毒滴度均无影响。这些发现提示：a）在小鼠脑细胞中，胡宁病毒感染基本无细胞病变；b）细胞介导的免疫反应导致发病和死亡，且不像其他病毒性脑炎那样能清除脑内病毒；c）ATS通过抑制或减弱对胡宁病毒的细胞介导反应可能具有治疗意义。
