Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan.
Pathol Int. 2013 Aug;63(8):415-8. doi: 10.1111/pin.12085.
Biliary tract cancer occurs frequently in patients with pancreaticobiliary maljunction (PBM), although no details of its clinicopathological characteristics have been reported. Here we describe a case of bile duct (BD) cancer that developed in association with PBM. This BD cancer involved the common channel, extended to the main pancreatic duct (MPD) via the common channel, and invaded the pancreatic parenchyma, where its growth and spread, and features of its recurrence, were similar to those of ductal carcinoma of the pancreas. We assumed that MPD extension of BD cancer via the common channel was the reason for its deep spread to the pancreas, since BD cancer usually spreads along the BD and rarely reaches the common channel of the ampulla of Vater. During the follow-up of patients with PBM, attention should be paid to involvement of the common channel by BD cancer and also to cancer developing silently in the pancreas after extrahepatic BD resection.
胆胰管合流异常患者常发生胆道癌，但目前尚无其临床病理特征的详细报道。本文报道了 1 例与胆胰管合流异常相关的胆管癌。该胆管癌累及共同通道，通过共同通道延伸至主胰管（MPD），侵犯胰腺实质，其生长和扩散以及复发特征与胰导管腺癌相似。我们推测胆管癌通过共同通道向 MPD 延伸是其向胰腺深部扩散的原因，因为胆管癌通常沿胆管扩散，很少到达 Vater 壶腹的共同通道。在胆胰管合流异常患者的随访中，应注意胆管癌累及共同通道的情况，以及肝外胆管切除术后胰腺内隐匿性发生的癌症。
