Respiratory Center, Asahikawa Medical University Hospital, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, Japan.
World J Surg Oncol. 2013 Aug 19;11(1):205. doi: 10.1186/1477-7819-11-205.
Combined large cell neuroendocrine carcinoma of the lungs (combined LCNEC) with giant cell carcinoma is extremely rare. A 65-year-old man was found to have an abnormal shadow in his left lung field. Computed tomography revealed a solid, round mass measuring 2.8 × 2.2 cm that was located in the left S9. The patient underwent left lower lobectomy and mediastinal lymph node dissection. Histopathological examination revealed an LCNEC, combined with giant cell carcinoma. The patient received by S-1 (TS-1, an oral fluoropyrimidine) chemotherapy, and he has been disease-free for over 8 months. Combined LCNEC with giant cell carcinoma is an extremely rare tumor with high malignant potential, and thus, multidisciplinary therapy and close follow-up are advised.
肺的大细胞神经内分泌癌合并巨细胞癌极其罕见。一位 65 岁男性被发现左肺野有异常阴影。计算机断层扫描显示位于左 S9 的实性、圆形肿块，大小为 2.8×2.2cm。患者接受了左肺下叶切除术和纵隔淋巴结清扫术。组织病理学检查显示 LCNEC 合并巨细胞癌。患者接受了 S-1（替吉奥胶囊，一种口服氟嘧啶）化疗，至今无病生存已超过 8 个月。大细胞神经内分泌癌合并巨细胞癌是一种恶性潜能极高的罕见肿瘤，因此建议采用多学科治疗和密切随访。
