Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
Phytochemistry. 2013 Nov;95:333-40. doi: 10.1016/j.phytochem.2013.07.022. Epub 2013 Aug 16.
Phytochemical investigation of the leaves of Ribes nigrum resulted in the isolation of fourteen compounds, including four 7,7'-epoxylignans, three tetrahydrofuran-type sesquilignans, and a spirocyclic dilignan. Their structures were elucidated by extensive spectroscopic analyses and by chemical transformations. The isolated compounds were evaluated for their antioxidant activities using superoxide anion scavenging assay and DPPH free radical scavenging assay. Ribesin D and ribesin G showed the most potent superoxide anion scavenging activity with EC50 values of 1.24 and 1.12 μM, respectively, and the structure-activity relationship was discussed.
黑果腺肋花楸叶的化学成分研究分离得到了 14 个化合物，包括 4 个 7,7'-环氧木脂素、3 个四氢呋喃型倍半木脂素和 1 个螺环二木脂素。通过广泛的光谱分析和化学转化确定了它们的结构。通过超氧阴离子清除 assay 和 DPPH 自由基清除 assay 评估了分离得到的化合物的抗氧化活性。Ribesin D 和 Ribesin G 表现出最强的超氧阴离子清除活性，EC50 值分别为 1.24 和 1.12 μM，讨论了结构-活性关系。
